How I Fixed Modafinil: Modafinil and Caffeine Stack

Modafinil and Caffeine

I’ve tried time and time again to use my modafinil as an as-needed supplement, but I find myself needing a pick-me-up more than once a week.

As much as I love caffeine, the effects are too short-lived to be effective for 16+ hours of productivity, so I turn to modafinil for a longer, cleaner feeling of wakefulness.

Plus, like everyone, I build a tolerance to caffeine pretty quickly. This means I need to take more and more caffeine to get the same effects as I did in early use stages. Since I use it for my pre workout supplement, I don’t want to rely on it to wake me up as well. This would just dilute its effectiveness. Thus, I turn to modafinil (to which I had no tolerance); however, it comes with similar drawbacks as well.

As many of you already know, modafinil and caffeine (as well as everything else) has a tolerance effect in the body, and I’ve almost reached a point of ineffectiveness. This happened to me once over the summer as well (I got to the point of taking modafinil every day) and it was an unfortunate waste of money.

Using Yohimbine to Counteract Modafinil Tolerance

I recently heard of a potential synergy between modafinil and yohimbine. I hadn’t done much research on yohimbine in the past, but it’s primarily marketed as a weight-loss supplement with stimulatory effects. I came across an article that mentioned that modafinil-induced wakefulness and focus was significantly increased with a small dose of yohimbine.

What are Yohimbine and Modafinil?

Here is a brief background of both supplements for those who are unfamiliar with them:

Modafinil is a drug that requires a prescription in the United States and is used to promote wakefulness. It is primarily used by individuals with narcolepsy or sleep apnea, but is also used for attention disorders, mood disorders, fatigue, and as a nootropic for cognitive enhancing purposes.

Yohimbine is available for purchase online and in many brick and mortar stores. It is primarily used for fat loss; however, it also has stimulant and aphrodisiac properties. As it is highly versatile, yohimbine is a very popular supplement among men and women. However, as I said before, I was interested in its potential synergy with modafinil.

Powder City was nice enough to send me a sample of yohimbine, and I was amazed with what I found.

It’s generally advised that these drugs should not mix (because yohimbine has inhibitor properties making modafinil slightly more toxic), but in low doses of each, this wasn’t a concern of mine.

I had made it through the entire week without the assistance of any supplements, but Friday came around and the entire week suddenly caught up with me. I finished class and had an hour or so before going to work, but sitting in my chair, I was having an insanely difficult time keeping my eyes open.

I didn’t want to take anything with caffeine in it, because I like to save my caffeine ingestion for the gym. I was about to take a quick powernap, but remembered that I had some yohimbine and modafinil on my shelf.

I cut the modafinil tablet in half (100mg), and took one capsule of yohimbine (2.5mg). Alone, these would not have done much for me, but together, I was awake and ready to go within half an hour.

After a shift at work, I went to the gym with one of my buddies who practices MMA (Mixed Martial Art) fighting all over the country, and with the help of a little caffeine powder, I was able to power through a 2-hour workout.

Individuals considering this combination should proceed with caution; yohimbine is highly stimulatory in some, but for me, it was just what I needed.

The Adrafinil Stack

Adrafinil is equally as effective as modafinil. This is because adrafinil is a prodrug of modafinil meaning it metabolizes into modafinil within the body. As a result, you reap the same benefits. Plus, you can stack adrafinil with other supplements as well. Also, unlike modafinil, you do not have to have a prescription to buy adrafinil.

Nootropic effects of Lucid Dreaming

lucid dreaming with nootropicsOnce, in Kindergarten, I had my first lucid dream. Being so young, it was amazing suddenly having complete control of my dream, having brought my conscious self into a subconscious world.

I don’t remember much about the dream specifically, but it sprouted into a curiosity of great potential. Many people claim they learn a lot through their dreams. A dream may have the potential to answer questions that bother some people on a daily basis, or have potential to generate new ideas/creations.

Lucid dreaming is that, but one step higher.

What is Lucid Dreaming?

It’s the ability to control what you get. I like to think of it as an opportunity to learn about myself. Imagine creating a room and sitting down across from an exact copy of yourself. You could literally ask your subconscious self any question, and hopefully receive an answer. Every day we try to hide from the truth, mask our emotions/thoughts, and create a fog over rational thinking.

The reason I think lucid dreaming could be a powerful nootropic is because it could be exactly what one needs to make great progress in their waking lives. While this isn’t a typical “cognitive enhancer”, I still think that what people try to achieve through supplementation could be achieved through dreaming.

Many use lucid dreaming as a playground, relieving stress, and becoming infinitely creative. People take nootropics for the same reason, which is why I believe that lucid dreaming is entirely underrated.

Steps to Achieve Lucid Dreaming

  1. Remember your dreams on a nightly basis: Many of us have a hard time remembering our dreams after we wake up, or claim we didn’t dream that night. As it turns out, we dream most night, but sometimes we just don’t remember it. This is known as recall memory. A good way to achieve this is to think back 20 minutes, and try to remember every detail up until the present moment. Another way is to keep a journal by your bed and as soon as you wake up, write down as much of the dream as you can remember, which exercises your recall memory.
  2. Reality checks: This is a term that is thrown around the lucid dreaming community quite often. Every chance you get, remind yourself that you are awake. Some people draw dots on their hands, look at a clock, or flick a light switch. When it reacts as one would expect, they tell themselves “I am awake because this worked”. Once done enough, that person might try a reality check in a dream and suddenly realize they are dreaming.

Lucid dreaming is hard to achieve and takes some people months to achieve just one so it takes practice. A few supplements to try to achieve lucid dreaming are DMAE and Galantamine, but many of the nootropics have this purported effect.

PRL 8-53 Dosage, Experience, Benefits and Memory

I was reading a book on nootropics titled Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances by David W. Group. While I feel a lot of the information was irrelevant towards my goals, I found one compound that sounded really interesting.

Merely known as PRL 8-53, this strange substance can apparently greatly increase one’s short term memory as well as memory formation given the right circumstances.

PRL 8-53 and Memory

Finding the right prl 8-53 dosage can help enhance memory.

If you’ve ever read a book on random facts, you might know that the reason a lot of phone numbers are only seven digits is because that is what most people are capable of memorizing after a couple seconds of studying.

I’ve tested my short term memory on, and sure enough, on the digit memory test, I can memorize seven digits fairly easily. However, while under the effects of PRL 8-53, test subjects could memorize around 21 digits. Talk about statistically significant!

This sounded way too good to be true to me, so I did a little reading on it. Unfortunately, all the research on it was from the 1970’s and is very limited. I have not been able to find a reason as to why research was discontinued, but several theories on the internet float around. Perhaps funding was discontinued from pharmaceutical companies. Everything I read about PRL 8-53 seemed positive with nothing negative. So why don’t people know about it?

A similar substance created by the same creator Dr. Nikolas R Hanis, called PRL 8-147, was studied in the early 1980’s at the University of Colorado at Boulder. Though not as widely-tested (PRL 8-147 never passed rodent testing), it is similar in function and structure.

It is possible to order this compound, as there are numerous companies in China that can synthesize it, but with little information, and most of that old, I’m not sure I’m too keen to test it. I may revisit the idea later, but for now, my noopept powder is sufficient.

PRL 8-53 Additional Benefits

Quick Facts
Scientific [1, 2]:

  • Improves short term memory in all individuals
  • Statistically significant increase in working memory for individuals with poor short term memory
  • No side effects noted in human trial

  • Anxiolytic effects in some, anxiogenic effects in others
  • Mixes poorly with antihistamines, causing tension headaches
  • Improves memory recall; degree of success varies from person to person

Given how popular this post is, I’ve decided to take another look at PRL 8-53 and see what new information has surfaced in the past year.

In the one human study done on PRL 8-53, there were some pretty amazing results. Each participant was given a placebo and PRL 8-53 at different times. They were then instructed to memorize 12 one syllable words.

While on the placebo, they experienced minor improvements in their memory tests. While on PRL 8-53, however, their scores often times doubled, even in individuals with poor short term memory [1].

Individuals with poor short term memory also saw additional benefits that those with strong short term memory did not. Working memory (keeping details in the brain until it can cement into long term memory) improved by a reasonable margin.

The study participants were asked to repeat back the memorized words after a 24 hours period and a 96 hour period. Individuals with poor short term memory saw marked improvement in their working memory; individuals with strong short term memory did not see a statistically significant increase.

So what does this mean for you? According to this study, individuals with poor short term memory can expect to see the greatest benefits. Not only will they be able to remember more information for short periods of time, their long term memory formation will see improvements as well. Individuals with strong short term memory can also experience benefits from PRL 8-53, but these are isolated to further improving their short term memory, but not memory formation.

PRL 8-53: Anecdotal Experiences

While PRL 8-53 only has one scientific study dedicated to human research, there are plenty of biohackers on reddit who have taken it upon themselves to give PRL 8-53 a try. By many accounts, PRL 8-53 is the strongest nootropic when it comes to actually feeling the effects. There is also debate as to whether it is actually a nootropic or a stimulant.

Nootropics to Try

PRL 8-53 recently became available on the market, but it is often hard to find. In the meantime, consider trying out some other well known, better tested nootropics.

Piracetam: This is the original racetam with the weakest potency. Piracetam is a good nootropic to start with for beginners.

Noopept: 1000x more potent than piracetam, noopept is an excellent brain booster. Many experienced noopept/nootropic users prefer noopept for its higher potency.

CDP Choline: This is good to take with racetams as it can mitigate any potential racetam headache. It is also has cognitive enhancing properties of its own.

What the redditors do agree on, however, is it certainly does seem easier to learn and remember information. The degree to how successful the memory recall and formation varies from user to user, but most individuals have had positive experiences.

In the same thread, however, one user complained of feeling “on edge and uncomfortable” particularly in social situations, but also while on their own as well. It also seems to interact poorly with antihistamines, causing tension headaches similar to caffeine withdrawal.

Another thread advises against taking PRL 8-53 sublingually as it numbs the mouth. Interestingly, this thread includes multiple accounts of anxiolytic effects, quite in contention with the previous account.

One user described it as “a combination of 2g phenethylamine and a 10mg dose of noopept. I feel that tingly/itchy feeling on my skin that I associate similar to phenethylamine and the anxiolytic effects of noopept”.

As this is a largely unstudied substance, it will probably be some time before true benefits and side effects are determined.

PRL 8-53 Dosage Information

I have to stress that it is not recommended at this time take PRL 8-53 as very few studies have been conducted. However, in the study referenced above individuals were given 5mg. The patent information available for PRL 8-53 suggests a range of 0.01-4mg/kg of bodyweight. However, as that is a very large range, the ideal range is 0.05-1.2 mg/kg [2]. This translates to 3.4mg-81.6mg for a 150 pound person and 4.55mg-109mg for a 200 pound person. In the human trial, no side effects were recorded; however, reduced motor activity was noted in mice and rats when given large doses of PRL 8-53 [2].

A far as the redditors’ dosing habits go, most agree effects set in quickly but the sensation of feeling the effects fade within 90 minutes or so. As such, many of them choose to take a 5mg dosage two to three times per day. So far, they have not reported any side effects of taking additional doses, but again I must stress they do so at their own risk.



Additional Reading About PRL 8 53


How Much GABA Should You Take for Sleep?

gaba-for-sleepHaving trouble sleeping? There could be numerous factors to consider why you are having this problem. But if traditional methods did not work for you to be able to attain that rest and sleep, then maybe you should try taking up a new supplement that might be able to help. One of these supplements that help you sleep better is known as GABA. But what is GABA? GABA (Gamma-aminobutyric acid) is a neurotransmitter in our brain known as a neuroinhibitor. In short, GABA acts as a balance for excitatory neurotransmitter in the brain, which most of the time dominates the brain itself. Excitation of the brain leads to issues like restlessness, anxiety, irritability, stress, and insomnia. GABA works to inhibit these issues and keep a check and balance in the brain. It serves to induce analgesia, relaxation, sleep. Thus, GABA supplement is effective in inducing sleep in people lacking it.

GABA Dosage for Sleep

But how are the dosages determined if you want to achieve a good night’s sleep? The standard GABA dosage is 250 mg, or one capsule. However, this might be quite small for some and would not have that much effect for sleep. As a result, some people take as much as 2 grams. Be cautious though, taking more than 2 grams can lead to side effects. Start with the lower dosage and work your way up to a level where you feel comfortable.

5-HTP for Weight Loss and Better Sleep

Awhile back, I heard about the world of lucid dreaming, and started getting very curious as to how I could consistently obtain lucid dreams. Lucid dreaming on its own can be an enormously powerful tool, though it can be incredibly hard to achieve. The first step to lucid dreaming is being able to remember your dreams.

My friend told me about 5-HTP and said that it made his dreams really vivid, and also helped him fall asleep. This was before I started taking melatonin, so I ordered some and tried it, and started to really like it. One potentially positive side effect is loss of appetite. I noticed I hardly needed to eat the next day (similar to many nootropics) and I felt fine. I didn’t remember my dreams however, but later learned that the ability to recall dreams is related to recall memory (which 5-HTP isn’t for).

I continued taking 5-HTP for sleep (slept soundly, all night), and the weight loss was a nice treat as well. I learned later that in some countries, 5-HTP is used to help alleviate symptoms of depression. The reason this stuff can make you happy, sleep better, and lose weight is because it’s a precursor to serotonin in the brain (though most serotonin ends up in the gastrointestinal tract).

But before you buy some and start taking it every night, you should be aware of some of the problems with 5-HTP as well. Because it increases serotonin in the body, it is possible for your body to adapt to this. Another thing to be conscious of is something known as serotonin syndrome. This is when too much serotonin gets into and stays in the brain and could be fatal, so proper dosing is vital.

I’ve personally stopped taking 5-HTP because I have melatonin for sleep, I’m trying to gain weight, and depression isn’t an issue for me. It’s still a powerful tool, that when used responsibly, could be a great addition to your supplement stack.

Top 5 Reasons to Try Phenibut

If you have not heard of this supplement called phenibut, now is a good time to take a good look and see exactly what it can do for your body. Phenibut was first discovered and used in Russia in their clinics for anxiolytic effects and as a nootropic to help with anxiety, stress, depression, and many other conditions. The phenibut dosages vary depending on what effect the user hopes to achieve.

Phenibut Effects and Benefits

1. It works. Phenibut has been used for a many number of years now, gaining popularity in Russian clinics. Many users attest to its ability to help them in their conditions. Many users take Phenibut powder to relieve anxiety and stress, although it can take quite a bit of time for this to kick in to your system once taken. But even with that feedback, there is just no denying that it’s effective. These days, it is alsoused to help people sleep better.

2. It is Safe. Did you know that this supplement was actually a standard in the health kit of Russian Astronauts in the early 70s? They used this supplement because it helped effectively reduce stress levels without affecting job performance. They could not rely on the traditional sedatives and tranquilizers as it made them drowsy.

3. It is cheap. You can buy 25g of Phenibut powder for under $10. You can find many deals and discounts online.

4. It can be used by both children and adult. There have been instances where even teens are using this to help keep their stress level in schools to a minimum. This is mainly because this is proven to really work well even with this young demographic.

5. It can improve memory, learning, and thinking. Now this is certainly something we can all use. People with memory problems or have difficulty in cognition can also use this. The so called nootropic effect has been proven before, and with the proper dosaging, you can actually utilize this supplement to enhance your brain power.