My Experience Buying and Taking Afobazole

If you buy afobazole, you may just unlock your mind.I believe Russia is the leading producer of new nootropics. They’re constantly coming out with new and promising things to try. After having great success with the racetam powder, I did a little reading to find what else I could take (hah, maybe curiosity got the better of me?). In case you’re wondering, there are many sources where noopept can be bought.

I came across this anxiolytic (anti-anxiety) stuff called Afobazole. I’m writing this with extreme caution because although I’ve taken it many times, I’m still unsure how safe it is – so be careful if you decide to try it. Disclaimers aside, Afobazole has been a great nootropic for me.

There’s almost no research in English on this particular nootropic, and at this point, everything is anecdotal. There are studies on this drug, but only the abstracts are in English. The rest of the studies are in Russion. However the Russion studies seem to claim it’s a safe compound with no known adverse side effects while taken alone or with other drugs. I’ve taken up to 20mg at a time (one tablet is 10mg) and I’ve been fine.

One point I have to make is that just because the studies do not claim negative interactions with other drugs, doesn’t mean it’s safe. There may be a negative interaction with drugs that warn not to take an MAOI since one study suggests that Afobazole is an MAO-A inhibitor.

Afobazole Effects

I notice myself feeling calmer and less self-critical. I tend to be a fairly self-conscious guy who can occasionally have a hard time in social settings, but on Afobazole (especially after several days of use, allowing it to build up in my system), I feel more at ease. Social interaction feel normal and there seems to be less pressure when I’m in public.

The Russians take pride in this nootropic drug because of its powerful anxiolytic properties while being non-sedating (typically, to find anything anxiolytic in the U.S. that is truly effective, a tradeoff is sedation). I certainly have not noticed any sedative effects with Afobazole and for this I am greatly appreciative.

Even though I find myself at ease, I’m still unsure if what I’m feeling is Afobazole or just placebo. Anti-anxiety meds are hard for me to measure because I still feel the same, yet overall more positive. Even if the effect is placebo, the fact is the drug is helping me through certain situations that might otherwise deter me. It’s made days go by easier and I’ve certainly enjoyed the experience. I might try to figure out a way to test the actual effectiveness of the drug by writing logs of how I am feeling throughout the days I take it versus the days I don’t.


The recommended dosage is 10 to 20mg 1 to 3 times daily. Start with a single 10-20mg dose to see if you have any negative side effects. Then wait until the next day before increasing to two doses.

L-theanine as an Afobazole Alternative

Because Afobazole is extremely difficult to purchase in the U.S., similar results can be obtained by taking a proper theanine dosage. It calms the body considerably, and is also commonly paired with caffeine supplements for a clean energy boost.

Other Alternatives

Ashwagandha is an adaptogen. Adaptogens are herbs that help the body deal with stress. Although not as strong as afobazole or phenibut in lowering socially prohibitive levels of anxiety, ashwagandha is a natural, and likely healthier, alternative.

Where to Buy Afobazol

You can purchase this from They seem to get rave reviews on reddit/r/nootropics.

Sulbutiamine Dosage, Description, and Experiences

Find the correct sulbutiamine dosage for increased focus and mental energyBeing faced with fatigue almost daily, my first goal in finding a nootropic was something that would give me energy all day long. That’s when I heard about sulbutiamine.

In Comes Sulbutiamine

Sulbutiamine is a synthetic version of the B-vitamin thiamine (B1). It was one of the first nootropics I tried and turned out to be a successful experiment. Even just reading about sulbutiamine before actually trying it was incredibly interesting to me.

Maybe it was because of how bizarre and multi-faceted its mechanisms seemed and how they affect the brain. A stimulant that causes an increase in the regulation of dopamine. [1]

What is Sulbutiamine?

Basically, sulbutiamine is a synthetic version of B1, thiamine, that can cross the blood-brain barrier much more efficiently than actual B1. It then raises the levels of thiamine and thiamine phosphate esters in the brain, increasing focus and endurance. [2]

It’s also a brain supplement that promotes increased cognitive energy and cognitive function. In some studies it has been shown to increase patient’s memories and help with the retention of knowledge. [2]

More specifically, sulbutiamine is two B1 molecules joined together. This was first synthesized after World War II when Japan’s population was facing Beriberi, or thiamine deficiency due to a lack of B vitamins in the diet. This relationship of thiamine deficiency and diet was discovered by Japanese navy surgeon, Takaki Kanehiro.

Sublutiamine owes its increased ability to pass the blood-brain barrier to its lipophilic profile. In other words, sulbutiamine is fat, or lipid, soluble. Lipid-soluble substances more easily pass this barrier since the blood-brain barrier consists of endothelium cells. These cells only allow lipids, glucose, oxygen, and carbon dioxide molecules across the barrier.

There is some evidence that sulbutiamine may be helpful with neurotransmission. Sulbutiamine has been shown to protect neurons within the brain from the effects of oxygen and glucose deprivation and can help treat symptoms of type II diabetes and diabetic neuropathy. [2]

Sulbutiamine Dosage

An important aspect to keep in mind is the correct dosage of sulbutiamine to take. I tried small doses at first to get a feel for the experience, but these did not seem to produce any noticeable effect. It was only once I got into the 800 mg and above zone that anything close to “stimulation” occurred. Even then, it was a far different effect than I was expecting.

If you’ve never taken sulbutiamine before, start with a 200mg dose to assess tolerance. This is ideal to start with to ensure you do not experience negative side effects. Most sulbutiamine capsules start around 200mg, which is convenient.

Most human studies use 400mg daily, but some individuals take up to 1000mg daily. Regardless of your ideal dosage, do not take sulbutiamine before bed as it has stimulant-like properties although it’s not technically a CNS stimulant.

Sulbutiamine Half-Life and Redosing

Its biological half-life is 5 hours. To account for this, redose at 50% of your starting dosage about once every 5 hours. For example, if you find your ideal dosage to be 400mg, then redose 200mg at 5 hours after your initial 400mg dose. Remember not to take this within 5 hours of bedtime.

Assuming you sleep at least 6 hours, this should equate to a maximum of 1 initial dose and 1 redose (possibly 2 redoses if you want to risk sleep issues).

Personal Experience with Sulbutiamine

While the brain chemistry was interesting, I found once I got my sulbutiamine dose high enough, the subjective effects were different than anything I expected. The energy felt “deeper” than a caffeine or even an amphetamine boost. Rather than feeling stimulated, I just felt awake. Completely awake. I had moments where I would feel drowsy, but, again, it all seemed to be “on top” of a deeper energy that I could tap into and move on.

You can use sulbutiamine as a caffeine substitute if you’re trying to quit or cycle off caffeine or your morning coffee. I was able to reduce my caffeine intake by over half on the days I supplemented with sulbutiamine. It’s also synergistic with caffeine, in case you just want to reduce your caffeine usage.

Wow This Stuff Works.

My language became more fluid and complex than usual, and there were undeniable empathogenic qualities that stimulants typically give me. I was talking to coworkers about their families, offering advice, and complimenting people genuinely whenever I could. It was here that I saw how effective Sulbutiamine powder could be as an anxiolytic product for people with social anxieties.

I have read in a few forums that some people build a tolerance rather quickly. Wanting to avoid a new tolerance or dependence was not in my plans so I never took Sulbutiamine three days in a row. This is probably a good rule of thumb, at least. I wouldn’t recommend non-stop usage, just a few days a week with breaks in between. [2]

Even though I never experienced any adverse effects, I need to mention that using high doses for weeks in a row can cause withdrawal symptoms if you stop cold turkey. Make sure you consult a doctor beforehand if you’re on any prescriptions as well since a case study does exist that shows a patient on antipsychotics growing addicted to this supplement. [2]

What I found was a very pleasant and powerful energy and anxiety aid. I look forward to my next shipment and hope it will be as good as the first.


Noopept vs Pramiracetam


The nootropics noopept and piracetam are two popular cognitive enhancers available on the market today. Both supplements are safe for consumption and are available in many countries.

Pramiracetam is a nootropic derived from piracetam and is considered to be more potent[1]. Noopept is a peptide-derived nootropic that is closely related to the racetam family.

Let’s go into a little detail on both of these supplements.

What is noopept?

This cognitive enhancer is said to be stronger than piracetam and thus much more potent (10-30mg of noopept vs. 2-4g of piracetam). This nootropic is a very popular memory supplement and is categorized as a neuroprotectant and psychostimulant[2].

How does noopept work?

Noopept ‘s mechanism of action is similar to the that of the racetam family. Despite noopept not technically being categorized as a recetam, its mechanism of action still entails stimulating the acetylcholine system as well as dopamine receptor sites. Acetylcholine is the neurotransmitter responsible for learning, so boosting the amount and duration of exposure is obviously a major plus. Furthermore, noopept also stimulates certain serotonin receptors which contributes to its mood boosting qualities[3].

Benefits of noopept

Noopept comes with many benefits:

• Increase in attention and memory
• Improvement in reflexes and perception
• Enhancement in logical thinking
• Boost in mood

The recommended dosage for noopept is 10-30mg taken daily. Noopept effects vary from person to person and some noticeable side effects include headache, insomnia, and fatigue. Since noopept is extremely potent, dosage should be strictly adhered to.

What is pramiracetam?

Pramiracetam is a nootropic that belongs to the racetam family and has been in use since the early 1980s. It shows potential in cognitive enhancement and is used to help alleviate symptoms of cognitive diseases [4].

Pramiracetam How does it Work?

Like its compatriots in the racetam family, pramiracetam works by increasing the uptake of choline in the brain thereby aiding in the efficient functioning of the acetylcholine system. This efficiency contributes greatly to memory formation and general cognition[5]. Such a mechanism of action has made pramiracetam one of the favorites among the cognitive enhancer supplements.

Pramiracetam Benefits

The most recognized benefits of pramiracetam include:
• Enhancement in mood
• Increase in long and short-term memory formation
• Increase in blood flow in the brain
Neuroprotective qualities
• Decreases the influence of amnesiac drugs

Pramiracetam Dosage

Pramiracetam is considered one of the strongest racetams; the recommended dosage is 250mg per day[6]. More experienced users of pramiracetam can take up to 400mg to 500mg twice daily. Due to the bitter taste that pramiracetam powder has, many users opt to purchase pramiracetam capsules instead (or flavors can be used to mask the taste as well). Be sure not to take pramiracetam sublingually as it may cause chemical burns.

Noopept vs Pramiracetam

Noopept and pramiracetam have also been used together in a nootropic stack and users claim that the emotionally dulling effect of pramiracetam counters the irritability effect of noopept. [7].

Both supplements are among the list of the strongest (produces the most noticeable effect) nootropics. For first-time users, increased mental clarity and enhanced cognition are noticeable[8].

If you haven’t taken these nootropics before, start with one at a time so you can experience their benefits in isolation. Then, if you decide to stack them you will have a higher chance of comprehending any synergistic effects of the stack.

As to the question of noopept vs pramiracetam and which among the two is the better nootropic, there isn’t always a definite answer. It would really depend for what you are aiming. One thing is for sure: these two supplements are among the strongest and should be handled with care. One deciding factor could be the methods of administration (see below).

I personally prefer noopept as it requires a much smaller dosage, so I don’t need to order very much at a time. Pramiracetam tends to make me too serious and limits my creativity.

Differences In Administration

Noopept’s cognitive enhancing effects are also more pronounces when taken sublingually, usually with a microscoop placed under the tongue. This usually isn’t done with pramiracetam since it can be caustic if kept in contact with areas under the tongue. Due to pramiracetam’s lack of dosage administration choices, you are forced to wait longer due to regular oral administration.



CDP Choline vs Alpha GPC and Choline Bitartrate

Synergy in Common Choline and Racetam Stacks

One of the difficulties most nootropic enthusiasts have upon building their latest stack is picking a choline source. There are good arguments for many choline forms, but I think that, ultimately, it comes down to a matter of priority and stack synergy. I’ve picked what I consider the big three (choline bitartrate, CDP choline, and Alpha GPC) and have shown what the benefits are for each.

Choline Bitartrate:

This should be an appealing choice for anyone who does not have the extra cash to pick up CDP-choline or Alpha GPC. That really appears to be its “synergistic” function. Going with bitartrate might allow you to afford another ingredient for your stack or even just afford your basic racetam/choline supplement combination if money is tight.

Choline bitartrate is the cheapest choline supplement, but it’s also the least bioavailable. Unlike, CDP Choline and alpha-GPC, the bitartrate form doesn’t easily cross the blood-brain barrier.

Bitartrate is a precursor to acetylcholine. This choline source is about 40% choline by weight. However, due to its limited bioavailability, the amount of acetylcholine this helps create is far less.

Despite its reduced potency, the bitartrate form of choline is still sufficient for liver benefits of choline. But due to its limitation in passing the blood-brain barrier, this form of choline has limited nootropic properties and lacked evidence in boosting memory in healthy adults (source).

CDP Choline:

CDP choline can be considered a nootropic on its own given the evidence that it increases dopamine and acetylcholine receptor density, improves memory, and provides mental energy. Also, CDP choline breaks down in the body into choline and uridine. [1] If you are taking DHA as part of your stack, this will help create phosphotidylcholine. [1] Since CDP choline readily crosses the blood-brain barrier, there is little concern for waste.

According to studies, this is the best choline format for combating memory-related issues due to aging. It’s also effective in boosting memory in young adults. Other non-nootropic uses include being used as an anti-addictive supplement against cocaine.

If you’re looking to boost memory or use in your uridine, or Mr Happy, stack then this is the optimal choline supplement. If you’re not familiar with this stack, see the original thread or the experiential post on

Alpha GPC:

Alpha GPC is another choline source with its own nootropic effects with or without a racetam through its ability to improve memory, focus, and concentration. [2] Alpha GPC is shown to also use DHA to help promote nerve growth. [2] Alpha GPC powder is usually the most expensive of the three forms shown.

Despite being the most expensive, this choline format is the most efficient source of choline and easily passes the blood-brain barrier due to its phospholipid properties.

In order for the body to use alpha-GPC it normally converts phosphatidylcholine stores in the brain. Phosphatidylcholine is used for the production of cell membranes. Dietary sources of alpha-GPC are scarce, which makes supplementing with this version almost necessary if you want to preserve your body’s phosphatidylcholine stores

Notes on stacks:

If your stack has Lion’s Mane or noopept (both increase nerve growth factor), Alpha GPC powder might not be the way to go. Through a simple racetam/CDP choline/DHA/noopept stack, it seems that the synergistic functions of the four compounds would benefit each other the most. Maybe add some creatine and sulbutiamine, and you’ve got yourself a perfect brain booster and wallet lightener.

  2. Kidd, Parris M. “Neurodegeneration From Mitochondrial Insufficiency: Nutrients, Stem Cells, Growth Factors, And Prospects For Brain Rebuilding Using Integrative Management.” Alternative Medicine Review10.4 (2005): 268-293. Academic Search Elite. Web. 8 Sept. 2012.