CDP Choline vs Alpha GPC and Choline Bitartrate

Synergy in Common Choline and Racetam Stacks

One of the difficulties most nootropic enthusiasts have upon building their latest stack is picking a choline source. There are good arguments for many choline forms, but I think that, ultimately, it comes down to a matter of priority and stack synergy. I’ve picked what I consider the big three (choline bitartrate, CDP choline, and Alpha GPC) and have shown what the benefits are for each.

Choline Bitartrate:

This should be an appealing choice for anyone who does not have the extra cash to pick up CDP-choline or Alpha GPC. That really appears to be its “synergistic” function. Going with bitartrate might allow you to afford another ingredient for your stack or even just afford your basic racetam/choline supplement combination if money is tight.

CDP Choline:

CDP choline can be considered a nootropic on its own given the evidence that it increases dopamine and acetylcholine receptor density, improves memory, and provides mental energy. Also, CDP choline breaks down in the body into choline and uridine. [1] If you are taking DHA as part of your stack, this will help create phosphotidylcholine. [1] Since CDP choline readily crosses the blood-brain barrier, there is little concern for waste. You can pick up some of this supplement here.

Alpha GPC:

Alpha GPC is another choline source with its own nootropic effects with or without a racetam through its ability to improve memory, focus, and concentration. [2] Alpha GPC is shown to also use DHA to help promote nerve growth. [2] Alpha GPC powder is usually the most expensive of the three forms shown.

Notes on stacks:

If your stack has Lion’s Mane or noopept (both increase nerve growth factor), Alpha GPC powder might not be the way to go. Through a simple racetam/CDP choline/DHA/noopept stack, it seems that the synergistic functions of the four compounds would benefit each other the most. Maybe add some creatine and sulbutiamine, and you’ve got yourself a perfect brain booster and wallet lightener.

  1. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2578826/
  2. Kidd, Parris M. “Neurodegeneration From Mitochondrial Insufficiency: Nutrients, Stem Cells, Growth Factors, And Prospects For Brain Rebuilding Using Integrative Management.” Alternative Medicine Review10.4 (2005): 268-293. Academic Search Elite. Web. 8 Sept. 2012.