A Six-Part Neuroprotective Stack for Longevity and Cognition

Priceless memories are often a computer crash away from being lost forever. Those crashes seem to come out of nowhere too, but that’s normally not the case.

First, you push your hard drive, not giving it any mind until the clicking starts. The clicking that lets you know things are going south, but that gets ignored, and before you know it, bad sectors (the parts that hold information) have filled up every inch of space until the drive no longer works and you have an oversized paperweight that used to house your cherished data.

Like your computer, your brain can accumulate damage over time that leads to failure, and no matter how quickly damage comes on, it’s usually a long time in the making and at a much higher cost.

This stack of six compounds is designed to prevent that damage from happening by protecting neurons, the basic building blocks of the Central Nervous System that transmit information throughout the body. When neurons die all sorts of cognitive complications arise [1].

Ashwagandha Extract – Intelligence and Protection

Ashwagandha extract is an Ayurvedic supplement revered for its use as an anxiolytic, cognition enhancer, and for its neuroprotective qualities, and for good reason since it protects neurons from oxidative stress. It does this by suppressing cortisol release while simultaneously activating choline acetyltransferase (an enzyme necessary in the production of the neurotransmitter choline), in turn causing enhanced serotonergic signaling and protection from neuronal death [2].

In other words, it protects brain cells and helps prevent health complications associated with neuronal death [1] by increasing the amount of chemicals related to a positive mood (serotonin) and decreasing those that promote stress and its related neurodegenerative chemicals (cortisol).

The most amazing benefit of Ashwagandha extract is the fact that it increases the growth of axons and dendrites [3]!

Axons and dendrites are the parts of neurons that transmit information between one another and the better their ability to do this, the more intelligence you have.

Already off to an impressive start, right?

Alpha GPC Powder – Free Radical Protection Plus Self Control

A choline supplement usually taken for nootropic purposes, Alpha GPC acts as a precursor to the neurotransmitter acetylcholine. Low supplies of acetylcholine have been associated with age related memory loss. Acetylcholine protects from free radicals and increases antioxidant production [4].

Alpha GPC powder can also help those that have trouble with self control and being overly impulsive. This impressive effect happens due to Alpha GPC’s ability to increase dopamine, serotonin, and GABA in the frontal cortex of the brain – the part of the brain responsible for emotional responses and decision making. The disruption of this area of the brain is the reason for impulsive behaviors [5], and increased dopamine has been linked to self control [6].

Not only is Alpha GPC powder much more than an “add on” to your nootropic stack, it has the ability to potentiate the next compound in this stack, piracetam.

Piracetam – Mental Clarity

Perhaps the most popular nootropic, piracetam offers benefits like increased communication between the two hemispheres of the brain by enhancing acetylcholine usage, improving long term memory, attention, and creativity [7].

Piracetam also improves mental functioning and clarity by restoring membrane fluidity while reducing oxidative stress [8].

Lithium orotate – Mood and Mental Protection

Lithium orotate is a mineral used to for a variety of conditions including attention disorders and it has shown effectiveness at lesser doses than lithium carbonate (its drug form requiring prescription) due to its ability to cross the blood-brain barrier [9].

Lithium appears to encourage GABA in the body while protecting against glutamate-induced toxicity and cell death, related to a number of diseases [10].

People that supplement with lithium orotate report having more self-control and improved mood.

Theanine Supplement – Promotes Health and Calm Focus

Theanine is another component of this stack that causes significant reversal of glutamate-induced toxicity [11].

It has been observed to demonstrate protective effects against oxidative damage while reversing and prohibiting cognitive impairments [12], and to reduce obsessive behavior [13] by increasing glycine [14]. In other studies, it has increased serotonin, dopamine, and GABA without increasing sleepiness [15] while inducing alpha waves in the mind (brainwaves associated with relaxed alertness) [16], promoting the perfect state of calm and mental focus.

Rhodiola Supplement – Adaptation and Longevity

Rhodiola rosea is another adaptogen in this stack, and Rhodiola’s upregulation of Neuropeptide Y is a big reason why [17]. This neuropeptide is a molecule in the brain that restores calm after stressful events, the stimulation of which both relaxes you and increases your ability to handle stress (like exercise for your stress-response)  [18], and this is believed to be a reason for its ability to increase mental and physical capacity [19].

Like many of this stack’s other supplements, Rhodiola has demonstrated antioxidant effects, but what’s really amazing are the results of a study that demonstrated Rhodiola has life-extending abilities [20].

The benefits of this stack compound upon one another and make for powerful neuroprotection while improving mental health.

Remember, it’s never too early to start taking care of your mind, but it can be too late.


  1. http://www.ninds.nih.gov/disorders/brain_basics/ninds_neuron.htm#death
  2. http://www.ncbi.nlm.nih.gov/pubmed/19444606
  3. http://www.ncbi.nlm.nih.gov/pubmed/12395110
  4. http://ageing.oxfordjournals.org/content/35/4/336.full
  5. http://ajp.psychiatryonline.org/article.aspx?articleid=175211&resultClick=1
  6. http://www.ncbi.nlm.nih.gov/pubmed/20428999
  7. http://www.ncbi.nlm.nih.gov/pubmed/1794001
  8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1615864/
  9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248201/
  10. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167234/
  11. http://www.ncbi.nlm.nih.gov/pubmed/23097345
  12. http://www.ncbi.nlm.nih.gov/pubmed/23395732
  13. http://www.hindawi.com/journals/np/2009/768398
  14. http://www.ncbi.nlm.nih.gov/pubmed/16493792
  15. http://www.ncbi.nlm.nih.gov/pubmed/17182482
  16. http://www.ncbi.nlm.nih.gov/pubmed/18296328
  17. http://www.ncbi.nlm.nih.gov/pubmed/22347152
  18. http://www.ncbi.nlm.nih.gov/pubmed/23272529
  19. http://www.ncbi.nlm.nih.gov/pubmed/20378318
  20. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660385/