PRL 8-53 and PRL 8-147: The Mystery

Nootropic users are always looking for an edge. As an advancing culture itself, there’s little surprise that nootropic communities are at the forefront of discovery. What was once a “push” system of manufacturers creating supplements and promoting them to the public has become a “pull” system of users discovering long-lost studies and demanding access to the best compounds available.

This is the case with a memory enhancing nootropic PRL 8-53 and a related, supposedly more powerful, compound called PRL 8-147. These are quickly becoming hot topics across the web and highly sought after nootropics with plenty of outstanding questions surrounding them.

The Origins of PRL 8-53

PRL-8-53

PRL-8-53 Chemical structure

PRL 8-53 can be traced back to one individual, Dr. Nikolaus Hansl of Creighton University. He discovered and patented the compound in the 1970s. Since then, there have been no major studies done on the compound. In fact, there is only one human-based study on PRL 8-53. However, that study along with animal studies have been enough to set the internet ablaze with curiosity about the compound, its effects, and its availability.

Participants showed an increase in short-term memory that remained over time as well as an 80% improvement in verbal memory. Current users report anecdotal evidence that memories formed while on PRL 8-53 are clear, vivid, and have tremendous staying power.

This makes PRL 8-53 a fantastic nootropic for students or anyone else going through a learning process. It’s shown even more improvements in individuals with existing memory conditions or who may have had a below average memory to begin with.  Other, less official sources report that PRL 8-53 can provide relief for victims of amnesia in a single dose.

The Mysterious PRL 8-147

Dr. Hansl reportedly synthesized a more potent version of PRL 8-53 called PRL 8-147. Online, this compound has achieved near-mythical status due to the lack of available information. This is where PRL 8-147 turns into more of a mystery novel than science report.

When Dr. Hansl died, the patents for his compounds and all of his research documents were left to his family, not a company, research facility, or school. With that in mind, a group of users on Reddit reached out to Dr. Hansl’s family to find out more about either of the compounds. They discovered that in addition to having a personal stash of PRL 8-147, Dr. Hansl’s daughter has a garage full of research and documentation.

PRL-8-147It’s believed that the keys to the PRL 8-147 mystery lie somewhere in her garage and, when uncovered, she would love to see her father’s discovery released to the public. After identifying the chemical structure of PRL 8-147, it’s likely some tests will be performed to create the correct compound and before long it will be available on the market.

So, if these are so great, why haven’t they been available before? It comes down to funding. When Dr. Hansl discovered the substances, he was unable to receive enough funding to perform proper large-scale tests and ultimately bring it to market. The initial holdup was most likely because it wasn’t a drug that set out to cure a particular disease or ailment.

Remember, in the 1970s nootropics weren’t a hot topic and without the internet information didn’t flow as freely as it does now. It was truly a discovery ahead of its time. That said, it wont be long before PRL 8-53 becomes a common nootropic and the mysteries of PRL 8-147 are uncovered and brought to the public.

PRL-8-53 and PRL 8-147 Safety

One of the biggest concerns when new products hit the market is safety. In a case like this, where there is very little relevant research, the concern is certainly understandable. As far as the studies Dr. Hansl did perform, neither human or animal studies had any conclusive evidence of PRL 8-53 being toxic. Dr. Hansl himself was reportedly a daily user of PRL 8-53 and suffered no known setbacks because of it.

PRL-8-53 Dosage

The mystery of PRL 8-53 continues into the realm of dosage. With only one proper human study, it’s been up to users to determine what their ideal dosage is. Since it seems to be relatively safe, most people greatly exceed the 5mg dosage used in Dr. Hansl’s research. Keep in mind this can be incredibly dangerous and is generally not recommended.

It’s only been about a year since PRL 8-53 really broke out, so more anecdotal reports of safety, experience and proper dosages are emerging every day. As PRL 8-53 becomes more popular and PRL 8-147 is uncovered, more studies will be performed to set worried minds at ease. Until then, if you’re looking for a massive memory boost and don’t mind being part of the initial experiments, PRL 8-53 could be a great nootropic to test out.

New Insight from Researcher

An individual reached out to Nootropics Hacks with hands-on inight behind these two nootropics. Here is what he had to say:

I was the person responsible for establishing the “rat study” with Dr. Hansl, at the University of Colorado, in Boulder, in the 1980′s. When I first mentioned to Nick that the initial test results were negative, his response was, “they didn’t treat the animals’ right!” In my opinion, the proper handling of test animals while conducting drug trials should be done with a sense of care. Particularly, where there is the need to assess accurately learning performance in their test subjects (that goes for animals and people as well). A researcher’s behavior should not be perceived as separate, from the whole process of the drug trial in animal studies, which includes injecting the test animal with a drug. The questionable handling of a test animal during a drug trial could indeed, affect the animal’s performance. When the final test results were presented to our group, the comment was made that “it doesn’t work” which was then followed with the remark, that it had “novel” results…perhaps, this could be interpreted as demonstrating, interestingly new or unusual results different from what was normally expected. In addition, as a matter of record, there were a number of studies conducted with the title compound PRL 8-147, in the late 1990’s, before the test at the University of Colorado in Boulder, were carried out:

Pharmacological Toxicological Characteristics of PRL-8-147, A New Psychotropic Agent.
Nikolaus R. Hansl, Creigton University, Omaha, Nebraska 68178

The title compound has recently attracted interest because it appears to improve performance based on intellectual capabilities. Acute and sub-acute toxicity studies reveal an LD50 of 171 mg/kg i.p. No significant signs of local irritation in the rabbit eye test were observed. Pyramiding doses of up to 320 mg/kg in the dog were well tolerated. No changes of the CBC or of the blood chemistry were found. The compound slightly depresses motor activity and partially reverses reserpine induced symptoms. Interaction with autonomic agonists in the isolated rabbit ileum and the anesthetized dog reveal an unusual spectrum of activity. A synergistic effect with acetylcholine, nor-epinephrine, dopamine, and isproterenol has been demonstrated. Effects of serotonin appear inhibited.

Furthermore, similar test were conducted on the title compound PRL-8-147 in mice, and in trials with other drugs…such as Amphetamine. I have included the above reference for those who believe, that PRL 8-147 was non-existent.

GPH

While it is impossible to verify the truth behind these claims, it is certainly fascinating information to have.

Sources

  • http://www.reddit.com/r/Nootropics/comments/1sqb2v/prl853_safety_long_term/
  • http://www.longecity.org/forum/topic/57942-prl-8-53;-was-prl-8-147-the-most-powerful-memory-enhancer/
  • http://en.wikipedia.org/wiki/PRL-8-53