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GABA vs. Phenibut—Which Actually Affects the Body’s GABA More?

GABA is considered to be the chief inhibitory neurotransmitter within the human body. It is responsible for slowing things down and helping to calm our mind and body. GABA is an essential chemical with a number of benefits. Another supplement known as Phenibut is also thought to act as a precursor to GABA. Although both are very effective, ultimately the real goal is to increase the level of GABA circulating in the brain and body. Which one is more effective as a supplement?

What is Phenibut?

Phenibut is a supplement that was developed in Russia during the Cold War. The timing is one of the reasons why it has escaped the attention of western research for so long. In fact, this supplement has been in widespread use throughout Russia and Eastern Europe since the 1970s. It is also part of the required pack for Russian cosmonauts.

In terms of structure, Phenibut is quite similar to GABA. The main difference is that its creators added a Phenyl ring of molecules to the GABA. This addition changed it into a different compound with one incredible benefit—it is capable of crossing the blood-brain barrier quite easily, something which natural GABA is not able to do.

Phenibut Powder Benefits:

The essential benefit of Phenibut Powder is that it absorbs into the bloodstream rather quickly and then enters into the central nervous system by crossing over the aforementioned blood-brain barrier. As it is then transformed into GABA, it has the effect of exerting an overall calm to the brain and body. You will feel the stress just melting away.

GABA Benefits:

Of course, GABA that is actually in the brain is capable of helping you to relax. This relaxation includes lower levels of stress, nervousness, and possibly even feelings of sadness. Overall mood will be enhanced. It is easier to fall asleep and wake up feeling refreshed.

Conclusion—GABA vs. Phenibut:

Assuming the main goal is to actually increase the level of GABA circulating within the brain, then there is no question that Phenibut is a better supplement. As a direct supplement, GABA is simply not able to cross over the blood-brain barrier and enter into the central nervous system.

Soybean-Derived vs. Bovine-Derived Phosphatidylserine

Phosphatidylserine is another supplement that has received a lot of attention in the past few years. There are a number of helpful benefits associated with it including an improved memory, mood, and a number of other cognitive functions. However, there seems to be a debate right now over which type of source makes for the best supplement. The two choices are soybean or bovine (cow) derived Phosphatidylserine. In order to make an informed decision, it is helpful to first know the benefits of this supplement.

What Is Phosphatidylserine?

This supplement is actually a natural ingredient or component of the membranes of living cells. This substance is found in the cell membrane of neurons (brain cells). Phosphatidylserine comprises as much as 10 percent of the lipid content of these cells. While it is possible to obtain this ingredient from food, we do not actually get very much this way. Average daily consumption is around 100 to 150 mg.

Phosphatidylserine Benefits:

This supplement is thought to regulate how brain cells work and process information. This is done by these membranes actually controlling which nutrients are used by the brain and which are passed out as waste products.

Another excellent benefit of this supplement is that it helps to improve communication between the various brain cells and hemispheres. This communication is thought to occur by increasing the number of receptors and increasing the production of Acetylcholine, a powerful neurotransmitter that plays a key role in memory formation, learning, and other cognitive functions.

While taking this supplement, memory is enhanced and so is the general speed of recall. Many users also report having much improved clarity and speed of thought. Attention span is increased and so are the abilities to concentrate and focus.

Phosphatidylserine Supplements: Bovine Or Soybean Derived?

In the past, most Phosphatidylserine was produced from bovine or cow sources. The raw ingredients were actually extracted from the brains of cows. Currently, most of the product on the market is soybean derived due to the FDA concerns about things like mad cow disease and other health issues. Almost all of the studies indicate the excellent benefits of this supplement were performed a few years ago using bovine derived sources.

There are some differences between the two sources. Bovine derived is usually attached to long chained polyunsaturated fatty acids (DHA or AA). The soybean derived variety is usually attached to saturated or monounsaturated fatty acids. While it does follow that many of the benefits should be similar, new studies need to be performed.

Using Nootropics for Motivation

Nootropic supplements are finding more and more uses in the area of brain enhancement. The term nootropic was originally coined in 1972 by Dr. Corneliu E. Giurgea and is derived from the Greek word “mind” and “to turn”- a fitting description of the alteration that these supplements can accomplish in the brain.

Nootropics can enhance memory, motivation, cognition, attention, alertness and more. Although the effect of each nootropics can help boost motivationsupplement will vary from person to person, there is always a common denominator.
The majority of the nootropics produce some form of motivation but let’s take a look at a few that have been especially noted to increase motivation:

Sulbutiamine

Sulbutiamine is a derivative of Vitamin B1. Because of its ability to cross the blood barrier faster than Vitamin B1, this supplement is stronger in terms of effects. Like thiamine, sulbutiamine works by aiding in the biosynthesis of acetylcholine and GABA but has a faster absorption rate.

Benefits of sulbutiamine include improved memory and stimulation. It has been used by athletes as a legal performance enhancer. Sulbutiamine causes upregulation of the reticular-activating system in the brain, which is the center of arousal and motivation.

Dosage of sulbutiamine is reported to be 12.5mg/kg although this may vary. Side effects include nausea, skin rash, headaches and anxiety. Thankfully there are nootropics for anxiety.

Aniracetam

Aniracetam is one of the most common racetams and is a cognitive enhancer known to enhance memory and concentration. It works by increasing communication between the left and right sides of the brain. This boost increases creativity, perception, and more. This supplement stimulates the function of neuronal receptors by means of glutamic acid which aids in the memorization process.

Aniracetam is usually stacked with choline in order to reduce the side effects that commonly occur with the use of aniracetam. Dosage of aniracetam is 1500mg taken twice a day in 750mg doses.

Vinpocetine

Vinpocetine is a cognitive enhancer that works by increasing the blood circulation in the brain. This increase in turn increases cellular efficiency. Additional benefits of vinpocetine include enhanced alertness and mood enhancement. Standard dosage of vinpocetine is 10mg taken three times a day.

Conclusion

When it comes to the search for nootropics for motivation, there are no hard rules. The fact remains that everyone reacts differently. It is noteworthy that supplements that have been considered to be good motivators, such as caffeine and amphetamines, can in fact have the opposite effect. According to a report, these stimulants do not actually raise motivation levels especially in individuals who are motivated.

With this in mind, one should carefully consider the nootropics taken for motivation—making the wrong choice can have negative effects. The aforementioned nootropics are what have been recommended by many.

Noopept vs Pramiracetam

 

The nootropics noopept and piracetam are two popular cognitive enhancers available on the market today. Both supplements are safe for consumption and are available in many countries.

Pramiracetam is a nootropic derived from piracetam and is considered to be more potent[1]. Noopept is a peptide-derived nootropic that is closely related to the racetam family.

Let’s go into a little detail on both of these supplements.

What is noopept?

This cognitive enhancer is said to be stronger than piracetam and thus much more potent (10-30mg of noopept vs. 2-4g of piracetam). This nootropic is a very popular memory supplement and is categorized as a neuroprotectant[2].

How does noopept work?

Noopept ‘s mechanism of action is similar to the that of the racetam family. This mechanism entails stimulating the acetylcholine system as well as dopamine receptor sites. Acetylcholine is the neurotransmitter responsible for learning, so boosting the amount and duration of exposure is obviously a major plus. Furthermore, noopept also stimulates certain serotonin receptors which contributes to its mood boosting qualities[3].

Benefits of noopept

Noopept comes with many benefits:

• Increase in attention and memory
• Improvement in reflexes and perception
• Enhancement in logical thinking
• Boost in mood

The recommended dosage for noopept is 10-30mg taken daily. Noopept effects vary from person to person and some noticeable side effects include headache, insomnia, and fatigue. Since noopept is extremely potent, dosage should be strictly adhered to.

What is pramiracetam?

Pramiracetam is a nootropic that belongs to the racetam family and has been in use since the early 1980s. It shows potential in cognitive enhancement and is used to help alleviate symptoms of cognitive diseases [4].

Pramiracetam How does it Work?

Like its compatriots in the racetam family, pramiracetam works by increasing the uptake of choline in the brain thereby aiding in the efficient functioning of the acetylcholine system. This efficiency contributes greatly to memory formation and general cognition[5]. Such a mechanism of action has made pramiracetam one of the favorites among the cognitive enhancer supplements.

Pramiracetam Benefits

The most recognized benefits of pramiracetam include:
• Enhancement in mood
• Increase in long and short-term memory
• Increase in blood flow in the brain
Neuroprotective qualities

Pramiracetam Dosage

Pramiracetam is considered one of the strongest racetams; the recommended dosage is 250mg per day[6]. Due to the bitter taste that pramiracetam powder has, many users opt to purchase pramiracetam capsules instead (or flavors can be used to mask the taste as well).

Noopept vs Pramiracetam

Noopept and pramiracetam have also been used together in a nootropic stack and users claim that the emotionally dulling effect of pramiracetam counters the irritability effect of noopept. [7].

Both supplements are among the list of the strongest (produces the most noticeable effect) nootropics. For first-time users, increased mental clarity and enhanced cognition are noticeable[8].

As to the question of noopept vs pramiracetam and which among the two is the better nootropic, there isn’t always a definite answer. It would really depend for what you are aiming. One thing is for sure: these two supplements are among the strongest and should be handled with care.

I personally prefer noopept as it requires a much smaller dosage, so I don’t need to order very much at a time.

Sources

1. http://en.wikipedia.org/wiki/Pramiracetam
2. http://www.ncbi.nlm.nih.gov/pubmed/2011259
3. http://onlinelibrary.wiley.com/doi/10.1002/ddr.430030503/abstract
4. http://www.braintropic.com/racetam-comparison/
5. http://www.longecity.org/forum/topic/60676-pramiracetam-noopept-exam-log/
6. http://www.whatarenootropics.com/what-best-racetam-nootropic/

Choline Bitartrate Benefits and Dosage Reviewed

What is Choline Bitartrate?

Choline bitartrate is part of the b-complex vitamin family and can be found in foods such as meat, peanuts, and eggs. It can be naturally produced by the body and it is also water soluble. However, it is also an essential nutrient and therefore should be included as part of a balanced diet. Choline supplements provide many health benefits and play an important role in helping the brain and nervous system to function properly. Choline is also essential in muscle contraction and movement and plays an important role in coordination. Research shows that choline may be effective in helping to prevent diseases such as arteriosclerosis and memory-related diseases.Choline bitartrate benefits brain health.

Choline Bitartrate Benefits

It is also recommended that women consume adequate amounts of choline bitartrate because it may reduce the risk of colon cancer and breast cancer. Additionally, in pregnant women a deficiency in choline could lead to an increased risk of premature birth. Lack of choline could also negatively affect the development of the baby’s memory. Choline is excreted through urine, similar to B vitamins, which could lead to a deficiency in the body. Supplementation of additional foods that are rich in choline can correct this deficiency.

There are many benefits of choline bitartrate including nerve development, transportation of fat through the body, and growth of cell membranes. It is also believed that choline is important for the brain and muscles to function. Generally, choline has been found to be important in both the maintenance and development of protection against disease. Choline also has the ability to protect and heal the liver and keeps fatty deposits in the liver from accumulating. Choline also promotes equal distribution of fat in the body. It is also said that choline supplements can help to prevent liver disease.

Choline bitartrate benefits include increased focus, memory formation, and muscle contraction. Studies have shown that choline supplementation can prevent neurological decline associated with aging. It has also been linked to reducing the levels of homocysteine which is a risk factor for heart disease. Many people take choline with piracetam and find that the two complement each other well. Choline can also be taken alone although it generally is not. Overall, choline has many health benefits and is especially helpful in preventing age-related memory decline. It can also be used as a cognitive enhancer and helps to improve memory. If you are searching for a supplement that has cognitive boosting properties then you may want to look into choline. However, you may also want to look into piracetam and consider mixing the two as many reviewers have reported the combination to be very effective.

Choline Bitartrate Dosage

The recommended choline bitartrate dosage is around 425 milligrams for women and 550 milligrams for men daily. It is said that during pregnancy higher dosages of around 550 milligrams may be needed although a healthcare practitioner should be consulted first for more accurate recommendations.

Where to Buy Choline Bitartrate: Powder, Capsules, Tubs

If you’re looking for a hiqh quality, affordable choline source, Powdercity.com offers Choline Bitartrate in powder, capsule and tub form. The bulk powder comes in 100g, 500g and 1kg variants and the capsules come in 30, 60 or 180 count bottles. The tub contains 100g of Choline Bitartrate powder.

Choline Bitartrate Sources

  1. http://www.ncbi.nlm.nih.gov/pubmed/21900997
  2. http://www.ncbi.nlm.nih.gov/pubmed/21118604
  3. http://www.ncbi.nlm.nih.gov/pubmed/21475195