Custom Acetylcholine Enhancing Stack

This is a post sent in to us by Eric Balaster of Pure Nootropics. I thank him for taking the time to write this. Opinions expressed are those of the author.

Most beginners to nootropics typically start with one of two combinations. The first is caffeine and L-theanine, which has a variety of studies that can prove the synergy between the two. The other includes piracetam and choline, which was one of the first nootropic stacks developed in the 1970s. Since then, thousands of people have found piracetam useful for preventing neurological decline and improving memory.

The supplementation of choline with piracetam strongly improves the effects in both animal and human trials. However, utilizing the right choline source can make the effects even more pronounced. The objective of the choline supplementation is to provide a precursor to acetylcholine, but this custom stack can prove more beneficial.

All Angles of Acetylcholine

My custom acetylcholine enhancing stack for use with racetams is particularly useful because it attacks all angles of the neurotransmitter. Rather than simply providing raw materials for acetylcholine synthesis, it is useful to consider enzyme blockers and synergistic compounds that can increase cognitive function.

CDP Choline

CDP choline is not the most efficient choline source by weight, but there are a number of advantages. Alternatives like soy lecithin and choline bitartrate are poorly absorbed and utilized for acetylcholine synthesis in the brain. CDP choline has the added benefit of creating cytidine, which is quickly converted into uridine [1]. Many studies point towards uridine for providing positive neuro protective capabilities as well, which makes it nearly as useful as choline.

Dosage: 200 – 525 mg / day


Although CDP choline provides some raw materials for choline and uridine production, acetyl-L-carnitine (ALCAR) is also a useful agent. It is a basic amino acid that provides a number of physiological benefits (especially for vegetarians), but is particularly useful for acetylcholine synthesis [2] to aid CDP choline.

Dosage: 500 – 750 mg / day

Spanish Sage

To compound the supplemented choline, Spanish sage is an excellent inhibitor of cholinesterase, which is the enzyme responsible for preventing full acetylcholine usage. Only small doses are required to have the desired effect [3], but young and healthy adults [4] respond well to this natural herb.

Dosage: 200 – 300 mg dried sage leaf / day

Diet and Tracking Your Stack

Depending on the types of foods that you eat, getting enough choline might not be a huge problem. There is a lot of choline in eggs, dairy products, and even some vegetables, so your supplementation will vary largely depending on your dietary intake. Furthermore, it is useful to track your cognitive abilities throughout the experimentation phase. You may find through subjective testing that your doses of these ingredients are too high (and thus causing a headache).

The only way to really know whether the piracetam and choline stack is working to improve your memory is through significant cognitive testing. Using enzyme inhibitors and the right types of choline for synergistic interaction can vastly improve the efficacy of nootropics.



About the Author

Eric Balaster is a self-described biohacker and nootropic lover. He has turned his interest of biology and physiology into a business called Pure Nootropics that offers independent third-party smart drugs for safe and convenient consumption.

The Poor Man’s Nootropic Stack

If you’re a college student or fresh graduate, you’re probably on a limited budget and don’t have a lot of money to spend on nootropics. However, your mental performance shouldn’t suffer just because you’re tight on cash.

In fact, with long nights studying and stressful exams, you could probably use a boost more than most people. Make no mistake, nootropics can get expensive, but like anything else, there’s a smart way to make your money work. You can build your own nootropic stacks that rival expensive blends for pennies on the dollar if you play your cards right.

Introducing: The Poor Man’s Nootropic Stack!

This stack is made up of essential nootropics that should serve as a baseline for anyone looking to save money on nootropics. In addition to being inexpensive, these are also very effective.

This stack includes nootropics that:

Limited funds? Don't sacrifice your brain power, try out the Poor Man's Nootropic stack!

Limited funds? Don’t sacrifice your brain power, try out the Poor Man’s Nootropic stack!

  1. Have a broad base of effects and lasting impact. These are considered the basics and a good foundation for any stack.
  2. Synergize with other nootropics included in the stack. These all work well together and, in some cases, will provide an added benefit over taking them individually.
  3. Are inexpensive. Since they’re the essentials, most are available in bulk powders or in other inexpensive forms that will allow you to stock up without breaking the bank.

Piracetam – Because it’s one of the oldest and most widely studied nootropics, piracetam is the superstar of the budget stack. Piracetam offers benefits for memory, learning, focus, concentration and mental performance in general. Bulk orders of piracetam can make it an extremely cost-effective supplement.

Caffeine – Caffeine has been used for ages by anyone trying to burn some midnight oil. What most people don’t know is that when used strategically, caffeine offers fantastic nootropic benefits. By consuming measured doses over time, caffeine can keep your mental energy levels steady and improve your focus. It’s also inexpensive. Bulk powder is available online, but if you want to go really cheap, you can consume coffee or other caffeinated beverages throughout the day in measured doses.

L-theanine – Providing anti-anxiety effects, l-theanine can be effective at helping you relax and focus. However, where it benefits you the most is when l-theanine is paired with caffeine. The two

Tea is a common source of theanine

Tea is a common source of theanine

have fantastic synergy that provides you with a calm, focused energy without caffeine jitters. This combination is already present at low levels in many teas; you’re just taking it up a notch to get the full effect.

CDP Choline – Choline is considered brain fuel. It keeps the furnace burning throughout the day and keeps you thinking sharp. Choline is another nootropic that offers synergistic benefits. Since piracetam increases choline uptake, adding a choline supplement can ensure that you’re getting the most out of your piracetam.

Noopept – Similar to piracetam, noopept is in the “racetam” family of nootropics. It offers the same benefits of improvements in memory, learning and mental performance. However, noopept powder is 1000x more potent than piracetam, so a much lower dose is required. Because of this, noopept makes a great addition to the Poor Man’s Nootropic stack with doses around $0.02 when purchased in bulk sizes.

Fish Oil – While not technically considered a nootropic, fish oil contains EPA and DHA which offer many neuroprotective benefits. In some cases fish oil has even been used to effectively deal with mood disorders.

That’s it! These are all you need to get smarter on a budget. Sure, it’s called the Poor Man’s Stack, but this could also be considered the “Smart Man’s Stack”. Why spend the money if you don’t have to? The nootropics listed here are enough to benefit anyone looking for a mental edge, no matter the budget!

Top Nootropics: Discover the Top 10 Nootropics

Top Nootropics Reviewed

Nootropics. Weird name, right? Believe it or not, you may have used a nootropic before without even knowing it!

If you work in a competitive business or are in college, chances are you’ve taken caffeine either in coffee, energy drinks, or supplement form. Caffeine is the world’s most widely-used and recognized nootropic.

Of course that does not mean it is the most effective. Many individuals are just simply unaware that there are better ways to focus while working or studying. What’s more, nootropics are able to unlock your cognitive potential!

So What Are Nootropics?

This unlocking does not mean you will suddenly find yourself in the premise of the movie Limitless, which brought nootropics to the attention of moviegoers everywhere. These aren’t magic powders to make you a genius. However, you may find you make connections more quickly, words flow more easily, and your motivation to get work done more readily available and longer lasting.

The word nootropic means “acting on the mind,” and that’s what these supplements are designed to do. They can enhance memory, cognitive function, and learning ability if taken correctly and at the right dosage.

There is a lot of information and misinformation available via the internet today concerning nootropics, especially when it comes to what is the best.

Top Nootropics

Below are the 10 top nootropics. This list is based on the effectiveness of the nootropic as a whole, the efficiency of the nootropic’s performance, and its accessibility to consumers:

  1. Noopept – Noopept is a quasi-member of the racetam family of nootropics and one of the most potent nootropics of its kind. It’s available in capsules as well as bulk powder. It improves cognition and enhances all the senses as well as imparts a great sense of physical, mental, and emotional well-being.
  2. Aniracetam – Another member of the racetam family, aniracetam helps creativity, memory, and intelligence; it also has anti-stress properties. For many beginners looking for a first nootropic to buy, aniracetam comes highly recommended.
  3. Pramiracetam – Pramiracetam can brighten up the brain and is great for those who suffer from poor concentration. Pramiracetam works in synergy with various other cognitive-enhancing products, such as choline, and as such has a very potent effect.
  4. Sulbutiamine – This is a synthesized version of Vitamin B1 (Thiamin) that helps elevate mood. It passes the blood-brain barrier with relative ease and helps elevate mood.
  5. L-theanine  – Interestingly, this is a non-essential amino acid which is most commonly found in tea. It is particularly good to take before an exam or presentation as it lowers stress levels. In combination with caffeine, l-theanine can give a calm, focused energy.
  6. NALT – N-Acetyl L-Tyrosine or NALT is an excellent mood elevator which enhances well-being and combats mental fatigue.
  7. CDP Choline  – This supplement is excellent for brain and neural function. Many users opt to stack choline with racetams as racetams often use up acetylcholine within the brain which can sometimes cause headaches.
  8. Alpha GPC – Another form of choline, this is found naturally both in milk and in the brain and has a positive effect on cognition.
  9. Beta Phenylethylamine (PEA) – PEA or phenylethlamine is primarily used for mood and has an effect which you are very likely to recognize. You know those feel good vibes you get from eating chocolate? Well this works in the same way, just way more concentrated and enhanced! It also stacks well with aniracetam to boost cognition.
  10. Phosphatidylserine – This is found naturally within cell membranes. As a nootropic, it’s a brain booster and memory enhancer.

So there you have it, the top nootropics supplements on the market. This article should be enough to equip you with the information to research and to ascertain which one(s) are best and most suitable for you, your lifestyle, and, of course, your budget.