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Brain Health and Adderall

With finals rapidly approaching, students are looking for any means to improve their memory and concentration. Students who have issues focusing may find that nootropics are not enough and will turn to prescription strength study aids instead.  Unfortunately, some of these prescriptions come with unwanted side effects.

Take Adderall, for example. Adderall works by stimulating the neurotransmitters dopamine and norepinephrine to enhance your attention and focus. However, it is neurotoxic to the dopaminergic system, which is responsible for regulating the reward pathway in your brain, motivation, and more. Thankfully, there are ways to reduce neurotoxicity.

How to Reduce Neurotoxicity

There are a variety of supplements that can help you reduce or avoid neurotoxicity due to Adderall. The supplements below provide a variety of benefits. Some help remove Adderall from your body at a rapid rate, some potentiate Adderall making it just as effective at smaller doses, and some help reduce neurotoxicity.

Vitamin C

  • Vitamin C: This is an antioxidant that can halt molecule oxidization. It can also remove Adderall from your system faster by acidifying your urine [1]. Plus, your body uses Vitamin C to produce dopamine. This is especially helpful if you took Adderall late in the day and it is interfering with your sleep.

Magnesium Aspartate

  • Magnesium aspartate: Magnesium deficiency has long been linked with the onset of ADHD [2]. It is also an NMDA antagonist, meaning it may be able to attenuate tolerance to Adderall as well as protect against its neurotoxic side effects [3]. This ingredient is also used on our mind-body connection stack for its recovery benefits.

Curcumin and piperine capsules

  • Curcumin and piperine capsules: This combination potentiates Adderall to allow individuals to use a lower dosage with similar effects. It is able to do this because it is a CYP450 enzyme family inhibitor [4, 5].

NAC

  • NAC: Adderall use depletes glutathione, an important antioxidant found in cells. Glutathione also improves the effectiveness of neurotransmitters [6]. N-Acetyl Cysteine (NAC) increases glutathione levels and can reduce neurotoxicity [7].

Melatonin

  • Melatonin: The stimulant effects of Adderall may keep you awake longer than you intended, but that is not why melatonin is on this list. Melatonin is a potent antioxidant and has proven to offset Adderall-induced neurotoxicity as it provides dopaminergic neuroprotection [8].

Fish oil capsules

  • Fish oil capsules: Omega-3 fatty acids increase dopamine levels and can naturally help improve your focus, meaning you could use a lower dosage of Adderall to achieve the same benefits [9, 10].

Uridine monophosphate

  • Uridine monophosphate: Uridine is able to create new dopamine receptors, particularly in brains with fewer receptors. Uridine can help balance dopamine levels altered by Adderall [11, 12]. When combined with DHA, uridine is able to boost mood as well [13].

By taking the proper precautions, you can significantly reduce the negative side effects of Adderall. Be sure to follow the proper dosage and usage guidelines to ensure the best results. Be sure to discuss any supplements with your doctor before taking them. Also check out our neuroprotective stack

Sources

  1. http://www.ahcmedia.com/articles/68649-drug-criteria-outcomes-dextroamphetamine-amphetamine-adderall-for-adhd
  2. http://www.ncbi.nlm.nih.gov/pubmed/9368235
  3. http://www.ncbi.nlm.nih.gov/pubmed/7690233
  4. http://m.dmd.aspetjournals.org/content/36/8/1594.full
  5. https://www.ncbi.nlm.nih.gov/pubmed/22185816
  6. https://www.ncbi.nlm.nih.gov/pubmed/23369637
  7. http://www.ncbi.nlm.nih.gov/pubmed/15234256
  8. http://www.ncbi.nlm.nih.gov/pubmed/19796048
  9. http://www.biomedcentral.com/content/pdf/1476-511X-6-21.pdf
  10. http://umm.edu/health/medical/altmed/supplement/omega3-fatty-acids
  11. http://ebm.sagepub.com/content/204/1/49.abstract
  12. http://cat.inist.fr/?aModele=afficheN&cpsidt=17035532
  13. http://www.ncbi.nlm.nih.gov/pubmed/15705349

The Poor Man’s Nootropic Stack

If you’re a college student or fresh graduate, you’re probably on a limited budget and don’t have a lot of money to spend on nootropics. However, your mental performance shouldn’t suffer just because you’re tight on cash.

In fact, with long nights studying and stressful exams, you could probably use a boost more than most people. Make no mistake, nootropics can get expensive, but like anything else, there’s a smart way to make your money work. You can build your own nootropic stacks that rival expensive blends for pennies on the dollar if you play your cards right.

Introducing: The Poor Man’s Nootropic Stack!

This stack is made up of essential nootropics that should serve as a baseline for anyone looking to save money on nootropics. In addition to being inexpensive, these are also very effective.

This stack includes nootropics that:

Limited funds? Don't sacrifice your brain power, try out the Poor Man's Nootropic stack!

Limited funds? Don’t sacrifice your brain power, try out the Poor Man’s Nootropic stack!

  1. Have a broad base of effects and lasting impact. These are considered the basics and a good foundation for any stack.
  2. Synergize with other nootropics included in the stack. These all work well together and, in some cases, will provide an added benefit over taking them individually.
  3. Are inexpensive. Since they’re the essentials, most are available in bulk powders or in other inexpensive forms that will allow you to stock up without breaking the bank.

Piracetam – Because it’s one of the oldest and most widely studied nootropics, piracetam is the superstar of the budget stack. Piracetam offers benefits for memory, learning, focus, concentration and mental performance in general. Bulk orders of piracetam can make it an extremely cost-effective supplement.

Caffeine – Caffeine has been used for ages by anyone trying to burn some midnight oil. What most people don’t know is that when used strategically, caffeine offers fantastic nootropic benefits. By consuming measured doses over time, caffeine can keep your mental energy levels steady and improve your focus. It’s also inexpensive. Bulk powder is available online, but if you want to go really cheap, you can consume coffee or other caffeinated beverages throughout the day in measured doses.

L-theanine – Providing anti-anxiety effects, l-theanine can be effective at helping you relax and focus. However, where it benefits you the most is when l-theanine is paired with caffeine. The two

Tea is a common source of theanine

Tea is a common source of theanine

have fantastic synergy that provides you with a calm, focused energy without caffeine jitters. This combination is already present at low levels in many teas; you’re just taking it up a notch to get the full effect.

CDP Choline – Choline is considered brain fuel. It keeps the furnace burning throughout the day and keeps you thinking sharp. Choline is another nootropic that offers synergistic benefits. Since piracetam increases choline uptake, adding a choline supplement can ensure that you’re getting the most out of your piracetam.

Noopept – Similar to piracetam, noopept is in the “racetam” family of nootropics. It offers the same benefits of improvements in memory, learning and mental performance. However, noopept powder is 1000x more potent than piracetam, so a much lower dose is required. Because of this, noopept makes a great addition to the Poor Man’s Nootropic stack with doses around $0.02 when purchased in bulk sizes.

Fish Oil – While not technically considered a nootropic, fish oil contains EPA and DHA which offer many neuroprotective benefits. In some cases fish oil has even been used to effectively deal with mood disorders.

That’s it! These are all you need to get smarter on a budget. Sure, it’s called the Poor Man’s Stack, but this could also be considered the “Smart Man’s Stack”. Why spend the money if you don’t have to? The nootropics listed here are enough to benefit anyone looking for a mental edge, no matter the budget!

Omega-3 Fish Oil for Boosting Mood

fish oil to boost moodNot everyone realizes that fats, more specifically fatty acids, are essential to good health. Yes, contrary to the popular opinion today that anything with fat in it is bad, you do need fatty acids in your diet in order to be in good health. Additionally, since fats are considered to be essential, the body cannot produce them on its own. These ingredients must be obtained through our food or supplementation. It is also interesting to note that evidence has been emerging showing that these oils can also help to boost our mood.

Omega-‘s and Mood:

We all know that sadness is a serious problem in our society. Those who suffer from poor mood spend lots of time seeking a way to boost mood. Omega-3 shows promise in this area. A British study used EFA, one of the best-known Omega-3s, to help deal with mood. After three months, over two-thirds of the treated group reported at least a 50 percent reduction in their sadness. This improvement was particularly true in the areas of sadness and pessimism, inability to work, sleeplessness, and low libido. If this supplement can work for them, it certainly can help an otherwise healthy person.

Important Role in Brain Health:

Most people have probably never realized but the nervous system is made up of mainly fats. All of the nerve impulses and signals that run across our bodies are sheathed in fat. And Omega-3 essential fatty acids are the basic building blocks of the brain. Neuronal cell membranes are about 20 percent fatty acids. Not only that, but they also appear to be critical at keeping the nerve signals and impulses working.

Although it is difficult to pinpoint exact mechanisms of action, it would appear that these fatty acids also help to maintain proper function of the brain and nervous system. Certainly, this maintenance can help to boost our mood, especially if we have been feeling a little “low” or “off.” Not only that, but it also may help your heart health. Plus, it has the effect of helping to reduce your “bad” cholesterol. As our bodily systems and functions become more efficient, our mood improves.