Powerful Anxiolytic Nootropic Combo: Rhodiola Rosea and Piracetam Supplement Stack

rhodiola plus piracetam for stress and cognitionIf the stress you’re feeling these days is hindering your ability to focus your thoughts at work or school, know you’re not alone.

In a ComPsych report published in Yahoo Finance, it was found that 62 percent of employees at work have significantly high levels of stress that have them feeling out of control or extremely fatigued.

And if you’re a student, you most likely have a multitude of stressors coming at you from every direction. A full semester of cramming, researching, and test taking can wreak havoc, leaving many students with difficulty concentrating, sleeping, or staying motivated.

If all this talk of stress has you feeling more stressed out, there are two supplements that when used in combination can help you to manage or alleviate much of your stress and improve your ability to focus while studying or working.

Rhodiola Rosea for Stress and Anxiety

Rhodiola Rosea supplement comes from an herb that grows in arctic regions of the world and dates as far back as the Vikings who credited the root as a source of endurance and strength while sailing.

Many studies have been done on this herb and Rhodiola has been found to have the ability to fight fatigue, enhance mental function and acuity, as well as improve sports performance.

Rhodiola is classified as an adaptogenic herb which means that it works through the adrenal glands to produce adjustments in the body that combat and increase resistance to stress without unwarranted side effects.

Rhodiola has also been studied as a positive aid for mood problems; so when you are feeling the effects of a stressful job or the pressure to get the grades, Rhodiola can aid the body in its response to both physical and emotional stressors.

Piracetam for Cognition

Piracetam, which typically comes in the form of piracetam powder is a widely-utilized and highly-recognized nootropic in the racetam family. This popular nootropic works by improving the function of the neurotransmitter acetylcholine through ACh receptors which are used in the memory process.

It has also been found to increase oxygen consumption to the brain which translates to a higher level of brain functioning. Think of it this way: consider the way our bodies function when we are stressed out. We take short, bated breaths from our chest and before we know it, we’re exhausted, we can’t concentrate, and our heads are pounding.

The brain functions in much the same way. Without its proper intake of oxygen, it doesn’t receive or produce commands correctly and it certainly isn’t doing anything at the speed we need it to.

Piracetam increases oxygen levels in the brain, allowing it to function at an accelerated level without the jitters or excitability of other stimulants. It continues to be one of the most popular nootropics as a result of its long list of benefits and few side effects.

Piracetam is one of the few nootropics that has little to no adverse effects when taken for long periods of time which translates to no heavy let downs or symptoms of withdrawl. What more could a college student cramming for a test or a stressed out worker putting in long hours wish for?

Powerful Anxiolytic Nootropic Combo

Now combine the two. An adaptogenic herb that helps your body more effectively respond to both stress and melancholy alongside a powerful cognitive enhancer that increases oxygen to the brain for optimal performance and focus.

Both mind and body are addressed, leaving the stress behind and allowing your mind to focus on getting the job done.

Dosages will vary from person to person and Rhodiola can be taken from 150mg, 3x daily up to 1-2g (total) daily safely with no reported side effects. Most positive effects were reported when taken morning, afternoon, and evening. The suggested serving for Piracetam is 2g, 1 to 2 times daily.

Omega-3 Fish Oil for Boosting Mood

fish oil to boost moodNot everyone realizes that fats, more specifically fatty acids, are essential to good health. Yes, contrary to the popular opinion today that anything with fat in it is bad, you do need fatty acids in your diet in order to be in good health. Additionally, since fats are considered to be essential, the body cannot produce them on its own. These ingredients must be obtained through our food or supplementation. It is also interesting to note that evidence has been emerging showing that these oils can also help to boost our mood.

Omega-‘s and Mood:

We all know that sadness is a serious problem in our society. Those who suffer from poor mood spend lots of time seeking a way to boost mood. Omega-3 shows promise in this area. A British study used EFA, one of the best-known Omega-3s, to help deal with mood. After three months, over two-thirds of the treated group reported at least a 50 percent reduction in their sadness. This improvement was particularly true in the areas of sadness and pessimism, inability to work, sleeplessness, and low libido. If this supplement can work for them, it certainly can help an otherwise healthy person.

Important Role in Brain Health:

Most people have probably never realized but the nervous system is made up of mainly fats. All of the nerve impulses and signals that run across our bodies are sheathed in fat. And Omega-3 essential fatty acids are the basic building blocks of the brain. Neuronal cell membranes are about 20 percent fatty acids. Not only that, but they also appear to be critical at keeping the nerve signals and impulses working.

Although it is difficult to pinpoint exact mechanisms of action, it would appear that these fatty acids also help to maintain proper function of the brain and nervous system. Certainly, this maintenance can help to boost our mood, especially if we have been feeling a little “low” or “off.” Not only that, but it also may help your heart health. Plus, it has the effect of helping to reduce your “bad” cholesterol. As our bodily systems and functions become more efficient, our mood improves.

Noopept and Exercise

Nootropics have become increasingly popular. Noopept is one of the newest entries in the family of racetams although it has a little bit different structure.

Noopept Defined

This peptide-derived supplement is closely related to the racetam family and was originally promoted in Russia and neighbouring countries. Noopept has been said to be more (up to 1000 times) powerful than piracetam (the first and most popular among the racetam family) and is therefore taken at a much lower dosage.


How does it work?

Like the other supplements in the racetam family, noopept is said to have a similar mechanism of action. Similar to piracetam, it has been shown to increase the spindle-like activity and alpha wave function in the brain. Noopept reacts with glutamatergic AMPA receptors, binding to them and thereby allowing them to move between brain cells, producing noopept’s effects in cognition. After consumption, the supplement is absorbed through the GI tract and has a very high oral bioavailability that enables easy blood-brain penetration. This crossing of the blood-brain barrier is the reason for the low dosage and high potency of the supplement.


What are the Noopept Effects and Dosing?

Like the other nootropics, noopept has the following effects:
• Enhanced memory and cognition;
• Lowered anxiety, irritability, and apathy;
• Mood-boosting qualities.

The recommended dosage of noopept is 10-40mg daily. One can obtain both noopept powder and capsules depending on preference. It is also a common practice to stack noopept with other nootropics such as choline or other racetams. However, considering the strength and cost of noopept, it is usually taken alone.


Does Noopept Help with Exercise?

According to users, noopept may have a positive effect on exercise. The effect that nootropics have on the brain is enough reason to believe that they can in turn affect exercise. Remember that everything we do starts in the brain. By enhancing the general performance of the brain, one can accomplish far more in the gym.

Enhanced perception and reflexes have been reported by noopept users, both of which are benefits that translate to exercise. According to information available on user forums, a common stack used to increase energy and focus is noopept and caffeine which users claim allows one to get more things done. Although the major noopept effects are on cognition and memory enhancement, like other racetams it is also able to aid in physical performance. Still, the intensity of the effect will vary from person to person.

Using Nootropics for Motivation

Nootropic supplements are finding more and more uses in the area of brain enhancement. The term nootropic was originally coined in 1972 by Dr. Corneliu E. Giurgea and is derived from the Greek word “mind” and “to turn”- a fitting description of the alteration that these supplements can accomplish in the brain.

Nootropics can enhance memory, motivation, cognition, attention, alertness and more. Although the effect of each nootropics can help boost motivationsupplement will vary from person to person, there is always a common denominator.
The majority of the nootropics produce some form of motivation but let’s take a look at a few that have been especially noted to increase motivation:


Sulbutiamine is a derivative of Vitamin B1. Because of its ability to cross the blood barrier faster than Vitamin B1, this supplement is stronger in terms of effects. Like thiamine, sulbutiamine works by aiding in the biosynthesis of acetylcholine and GABA but has a faster absorption rate.

Benefits of sulbutiamine include improved memory and stimulation. It has been used by athletes as a legal performance enhancer. Sulbutiamine causes upregulation of the reticular-activating system in the brain, which is the center of arousal and motivation.

Dosage of sulbutiamine is reported to be 12.5mg/kg although this may vary. Side effects include nausea, skin rash, headaches and anxiety. Thankfully there are nootropics for anxiety.


Aniracetam is one of the most common racetams and is a cognitive enhancer known to enhance memory and concentration. It works by increasing communication between the left and right sides of the brain. This boost increases creativity, perception, and more. This supplement stimulates the function of neuronal receptors by means of glutamic acid which aids in the memorization process.

Aniracetam is usually stacked with choline in order to reduce the side effects that commonly occur with the use of aniracetam. Dosage of aniracetam is 1500mg taken twice a day in 750mg doses.


Vinpocetine is a cognitive enhancer that works by increasing the blood circulation in the brain. This increase in turn increases cellular efficiency. Additional benefits of vinpocetine include enhanced alertness and mood enhancement. Standard dosage of vinpocetine is 10mg taken three times a day.


When it comes to the search for nootropics for motivation, there are no hard rules. The fact remains that everyone reacts differently. It is noteworthy that supplements that have been considered to be good motivators, such as caffeine and amphetamines, can in fact have the opposite effect. According to a report, these stimulants do not actually raise motivation levels especially in individuals who are motivated.

With this in mind, one should carefully consider the nootropics taken for motivation—making the wrong choice can have negative effects. The aforementioned nootropics are what have been recommended by many.

Noopept and Megadosing


Noopept has noticeable nootropic effects due to its high potency. Many people use noopept to improve mood, focus, and motivation.

What is Noopept?

Scientifically known as N-phenylacetyl-L-prolylglycine ethyl ester, this nootropic supplement is patented in the United States and in Russia where it is commonly used. Noopept derives from the racetam family and works in a similar manner as the other racetams but is up to 1000 times more potent than the most common racetam, piracetam.

Noopept is a peptide (a compound consisting of two or more amino acids linked in a chain) that has been shown to be more powerful than Piracetam. Aside from being a brain booster, it is also reported to have anti-inflammatory benefits and antioxidant qualities.

How does it work?

The method of action used by noopept is similar to the group of cognitive enhancers called racetams. Although the exact way that racetams function is yet to be understood, these compounds are said to work by activating the glutamic receptors and inhibiting the hydrolization of acetylcholine in the brain. The breakdown of acetylcholine (the brain’s primary neurotransmitter) is what causes memory loss and other degenerative effects in terms of cognition. Noopept also seems to stimulate an anxiolytic response in animal and human models as well as dopamine receptor and serotonin-receptor sites.

What are the benefits?

Some of the noticeable noopept effects are:

  • Increased overall cognitive performance,
  • Increased learning ability,
  • Enhanced memory,
  • Improved reflexes and perception,
  • Improved mood.

Noopept and Megadosing

The recommended dosage for noopept is 10-40mg a day. Noopept is known to be one of the nootropics that produces noticeable effects after short usage. This rapid action makes it a highly-potent supplement that is recommended to be taken carefully.

A common practice when it comes to supplementing with nootropics is called megadosing. Megadosing is the consumption of an exceptionally large dose of a supplement. In the case of noopept, some users have experimented with megadoses and received good results. Megadosing with up to 100mg of Noopept twice a day improves mood, sensory enhancement, and general cognition.

Before you decide to megadose with noopept, it is important to assess your tolerance at lower dosages.

Noopept vs Pramiracetam


The nootropics noopept and piracetam are two popular cognitive enhancers available on the market today. Both supplements are safe for consumption and are available in many countries.

Pramiracetam is a nootropic derived from piracetam and is considered to be more potent[1]. Noopept is a peptide-derived nootropic that is closely related to the racetam family.

Let’s go into a little detail on both of these supplements.

What is noopept?

This cognitive enhancer is said to be stronger than piracetam and thus much more potent (10-30mg of noopept vs. 2-4g of piracetam). This nootropic is a very popular memory supplement and is categorized as a neuroprotectant[2].

How does noopept work?

Noopept ‘s mechanism of action is similar to the that of the racetam family. This mechanism entails stimulating the acetylcholine system as well as dopamine receptor sites. Acetylcholine is the neurotransmitter responsible for learning, so boosting the amount and duration of exposure is obviously a major plus. Furthermore, noopept also stimulates certain serotonin receptors which contributes to its mood boosting qualities[3].

Benefits of noopept

Noopept comes with many benefits:

• Increase in attention and memory
• Improvement in reflexes and perception
• Enhancement in logical thinking
• Boost in mood

The recommended dosage for noopept is 10-30mg taken daily. Noopept effects vary from person to person and some noticeable side effects include headache, insomnia, and fatigue. Since noopept is extremely potent, dosage should be strictly adhered to.

What is pramiracetam?

Pramiracetam is a nootropic that belongs to the racetam family and has been in use since the early 1980s. It shows potential in cognitive enhancement and is used to help alleviate symptoms of cognitive diseases [4].

Pramiracetam How does it Work?

Like its compatriots in the racetam family, pramiracetam works by increasing the uptake of choline in the brain thereby aiding in the efficient functioning of the acetylcholine system. This efficiency contributes greatly to memory formation and general cognition[5]. Such a mechanism of action has made pramiracetam one of the favorites among the cognitive enhancer supplements.

Pramiracetam Benefits

The most recognized benefits of pramiracetam include:
• Enhancement in mood
• Increase in long and short-term memory
• Increase in blood flow in the brain
Neuroprotective qualities

Pramiracetam Dosage

Pramiracetam is considered one of the strongest racetams; the recommended dosage is 250mg per day[6]. Due to the bitter taste that pramiracetam powder has, many users opt to purchase pramiracetam capsules instead (or flavors can be used to mask the taste as well).

Noopept vs Pramiracetam

Noopept and pramiracetam have also been used together in a nootropic stack and users claim that the emotionally dulling effect of pramiracetam counters the irritability effect of noopept. [7].

Both supplements are among the list of the strongest (produces the most noticeable effect) nootropics. For first-time users, increased mental clarity and enhanced cognition are noticeable[8].

As to the question of noopept vs pramiracetam and which among the two is the better nootropic, there isn’t always a definite answer. It would really depend for what you are aiming. One thing is for sure: these two supplements are among the strongest and should be handled with care.

I personally prefer noopept as it requires a much smaller dosage, so I don’t need to order very much at a time.



Hordenine and PEA (Phenylethylamine) Supplements

Falling in love or having a crush on someone can be a very powerful feeling. The exhilarating rush makes everything else seem insignificant.

An often overlooked part of the whole idea, especially when you’re in the middle of the emotions, is that the rush is all a result of a chemical cocktail mixed by the brain.

Even though it’s more fun to get the chemicals flowing naturally, two supplements, the PEA Hordenine combo, can help mimic the same euphoria felt with that kind of intense happiness while improving brain function, boosting physical performance, and also helping you burn fat.

PEA Phenylethylamine Supplement Benefits

Phenylethylamine (also known by the much easier to pronounce acronym ‘PEA’) is a natural alkaloid found throughout nature in animals and plants. It is a neuromodulator and neurotransmitter.  Individuals often use PEA as a dietary supplement to boost mood and energy. When metabolized, PEA acts similarly to an amphetamine by releasing a special mix of the endorphins norepinephrine and dopamine and speeding up the flow between nerve cells.

Due to this, it’s come to be known as the “love molecule” or an infatuation inducing stimulant and creates the high or euphoria felt when in love. There seems to be an optimal range of PEA within the body as people who have problems focusing their attention often have low levels of PEA, while people with certain psychological issues often have abnormally high levels.

If PEA sounds like it’s too good to be true, that’s because it is. When used alone, PEA is quickly made inactive by monoamine oxidase (MAO). This means very little reaches the brain and even if it does, the effects don’t last very long.

Phenylethylamine Hordenine Benefits

This is where hordenine comes in. Hordenine is an alkaloid extracted from specific type of cactus and in the class of PEA-related chemicals. It also affects levels of norepinephrine within the body and is used as a stand alone supplement for energy, weight loss, body composition, and improved cognitive function.

But when it relates to PEA, the most sought after effects of hordenine are for it acting as an MAO inhibitor. Since MAO quickly breaks down PEA when it’s metabolized, the effects are short lasting. But when combined with the MAOI-like effects of a supplement like hordenine, the positive feelings from PEA can carry on much longer and possibly be amplified.

While the chemical effects of stacking hordenine phenylethylamine are the same, they benefit users in a variety of ways from a planned euphoria during social events on the weekends to energetic, focused workouts. The main uses of PEA/Hordenine are:

  • Induce a positive mood
  • General euphoric feelings
  • Focus and concentration
  • Energy before a workout
  • Fat loss (Stimulant)

If you are interested in testing out a combo of hordenine phenylethylamine, especially if you’re mixing bulk powders, you will likely have to experiment to find the dosage that works best for you. Some users like to take 15-30mg of Hordenine with 300-500mg PEA.

As always, it’s best to start on the lower end of the dosage spectrum and slowly work up from there. You can find both PEA and Hordenine at PowderCity.

Hordenine and PEA (Phenylethylamine) Sources