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Piracetam, Noopept, Theanine and Caffeine: Hack your Brain for Increased Productivity

You’re going to run a marathon. You’ve already decided. Well, in your heart at least, because you still haven’t gotten off the couch to start that elaborate training routine you’ve come up with.

So what do you do in the meantime? Dream up how great it will be when you finally run. The adrenaline as you pass over the finish line, the cheers from your friend and family, the pride that you’ll feel. Dreaming big will make sure that you act big, won’t it? After all, you need concrete goals to get anywhere.

Take those big dreams, toss in some supplements for focus, maybe a few more supplements for concentration, and you’re pretty much guaranteed to succeed. Right?

Unfortunately some recent studies indicate not necessarily [1]. One study had some participants envision a happy resolution to a crisis in another country, while the rest were just asked to state the facts of the crisis. When later asked to donate $25 or more, it turns out the participants who only recited cold facts were much more likely to donate.

The results were repeated in two more trials. One used similar procedures (this time related to donating time to a charity) while the other replaced stating the facts with imagining wasting time — establishing that it wasn’t stating facts that increased will to act, but it was positive dreaming that reduced it.

The takeaway here is that, to a certain extent, positive fantasies reduce the amount of effort you’re willing to put into making that fantasy come true. The downside is that it’s not exactly easy to quit daydreaming. Every second you spend distracted from a task is very likely a second you’re going to spend imagining how great it will feel once you finish.

Fortunately with nootropics, it’s not just a matter of you trying to force yourself to focus. By adding a few crucial supplements for focus to your daily routine, you can watch your concentration skyrocket. Less time dreaming, more time doing — what more could you ask for?

Piracetam

Start off your pursuit of boosted concentration with piracetam powder, one of the oldest and most widely researched nootropics out there. Before we go any further on its concentration-boosting benefits, take a moment to consider that piracetam also shows promise for positive effects on cognition, learning, and memory [1]. If your area-of-needed focus is academic or otherwise cognitively oriented, you’re looking at added benefits from piracetam straight from the get go.

On to its benefits for focus and concentration: Piracetam has repeatedly shown itself to benefit both, allowing users to participate in tasks for longer, less interrupted stints — it makes cognitive flow easier. Piracetam, an AMPA modulator, induces this effect by increasing the amount of oxygen that gets to the brain [2]. Communication between brain hemispheres is boosted, manifesting as a feeling of focus and clarity.

Noopept

If piracetam isn’t quite cutting it or you’re just looking to up your edge even further, check out noopept. It’s actually derived from the racetam family, meaning that it has some similarities to piracetam. It’s definitely its own beast though, and you’ll find a clear cut illustration of the differences before you even start to read up on the effects. While a typical piracetam dose will run between 1 to 3 grams, noopept powder is about a thousand times stronger, working efficiently at doses as small as 10 mg [3].

This might make you think it’s simply a jacked up piracetam, but noopept has its own distinct effects. Noopept is touted for anti-anxiety benefits in addition to its cognitive gains [4]. The upshot of this is that you spend less time worrying — if you aren’t worrying, it’s a heck of a lot easier to stop working. Add in the facts that noopept has shown to be neuroprotective and that its effects actually build over time [5], and you’re looking at a very potent productivity aid.

Caffeine and Theanine

Last but not least, a knock-out combo that will see your morning coffee benefiting you in completely new ways. While both of the following are effective supplements for concentration on their own, mixing l-theanine and caffeine powder will produce a synergistic effect that goes well beyond what you’d get from taking either individually.

Theanine is actually an amino acid that you’ve probably come across before without realizing it: it’s found in green tea. Taken on its own, it affects both your GABA and glutumate receptors, and is well-documented for having calming, relaxing effects [6].

Caffeine on its own stimulates a whole slew of neurotransmitters, but leaves you feeling wired and sets you up for an eventual crash. Together? Theanine takes the edge off of caffeine, smooths out the comedown, and makes it much easier to focus. A trialed study found that participants on a combination of theanine and caffeine were much better at focusing on difficult cognitive tasks [7]. So next time you grab a coffee to give yourself energy boosts, add in some theanine – and unlock your full potential.

Focus and concentration don’t come easy, and even with nootropic supplementation require discipline and practice. With the right stack, though, it’s possible to “hack” your brain into increased productivity. Experiment with combinations and compounds, find what works best for you, and boot those endless daydreams out of your head!

Sources

  1. http://www.psychologytoday.com/blog/ulterior-motives/201302/positive-fantasies-can-reduce-future-effort
  2. http://examine.com/supplements/Piracetam/
  3. http://www.ncbi.nlm.nih.gov/pubmed/12596521
  4. http://examine.com/supplements/Noopept/
  5. http://www.braintropic.com/noopept/
  6. http://examine.com/supplements/Theanine/
  7. http://www.ncbi.nlm.nih.gov/pubmed/18681988

Mind-Body Connection Stack Critique

A reader recently wrote in asking for my input on their theoretical stack. After looking it over I realized this was a fairly extensive question that deserved a detailed response.

Many nootropic stacks are geared toward boosting one particular thing, usually memory or intelligence. But what about a stack that doesn’t stimulate a certain area per-se so much as give you an all-around platform for mental and physical health?

Keeping your brain and body healthy while building a strong mind and body connection is a sure fire way to see cognitive improvements across the board. It’s not just about enhancing your brain: it’s about giving your body the nutritional tools to keep itself in tip-top shape. Supplementation can be tricky, though, since overstimulation of one part of your brain can have negative effects on others.

If you’re looking for a more holistic stack, it’s crucial you have the right mix of supplements taken at the right time in the right combinations. With that in mind, here’s a three-part daily stack designed to maximize your brain’s own innate potential.

Morning (before meal):

Caffeine 50 mg
L-theanine 100 mg
Noopept 20 mg
Lion’s Mane Extract 1000 mg

Morning (after meal):

Pramiracetam 250 mg
Choline Bitarte 500 mg

Before work-out (or other exercise):

Rhodiola Rosea 250 mg
ALCAR 500 mg
Ashwaganda Root 950 mg
Lion’s Mane 1000 mg

Evening, before bed

L-theanine 100 mg
Valerian Root 200 mg
Magnesium 400 mg
GABA 400mg

Now it’s time for a closer examination of the how and why of this stack. Essentially, it’s targeting three crucial aspects of holistic health: focus, energy, and rest. A substance-by-substance breakdown of how you’re benefitting from this stack:

FOCUS

Caffeine/Theanine: Caffeine’s stimulatory effects aren’t exactly a secret; caffeine is the most common nootropic, even though it’s not usually perceived as such.  Here’s the thing: it’s way more than a jittery energy booster that makes you crash a few hours later.

Caffeine increases levels of numerous neurotransmitters – norepinephrine, acetylcholine, dopamine, serotonin, epinephrine, and glutamate [1]. All of these are associated with focus and mental performance. Its critical downside is its notorious “crash”. This is where a theanine supplement comes in.

Theanine, found naturally in green tea, boosts and normalizes your GABA function [2]. Broken down, this has a calming affect which is directly synergistic with caffeine. Add a spoonful of a theanine in your morning coffee and you’re basically looking at all the benefits of caffeine minus the crash and jitteriness [3]. It’s hands-down the ideal way to kick off your daily nootropic regime. Take theanine on its own in the evening to settle into a calm, relaxed state.

Noopept: An offspring of the esteemed racetam family, noopept has shown to have dramatic impacts on memory and cognition with little to no side effects [4]. Even better, noopept powder also boosts neuroprotective effects. So you’re not only improving your focus with a daily dose of a noopept powder – you’re making your brain safer and stronger.

Lion’s Mane Extract: Extract from lion’s mane mushrooms has a unique function: it stimulates nerve growth factor, or NGF [5]. NGF belongs to a family of proteins that play a part in maintaining and regenerating neurons during our adult life. Bad news is as we age, our body produces less and less.

Lion’s mane, however, ensures high levels. Absence of NGF has been linked to age related memory loss [6], so if you’re looking for long-term upkeep of your cognitive health, lion’s mane is crucial. You’ll want to take it again later, since cumulative dosing is more effective.

Pramiracetam/Choline: Pramiracetam, usually found in the form of pramiracetam powder, is a bit different from other substances on this list in that it’s fat-soluble. In other words, pramiracetam powder won’t get metabolized correctly if it isn’t broken down by some fat or oil. This makes it an ideal substance to follow up with after a meal. Taking pramiracetam with a choline source boosts pramiracetam powder’s efficacy while simultaneously keeping your acetylcholine levels from dropping too low.

ENERGY/PRE-WORKOUT

Rhodiola Rosea: Rhodiola Rosea is derived from a flower that has been used for centuries to prevent fatigue. As an adaptogen, it both stabilizes your physiological processes and reduces stress on cells. It gives you energy, boosts focus, and allows your body to work harder and longer with less fatigue [7]. It’s an ideal supplement to any physical activity – which is itself crucial to a healthy mind-body connection.

ALCAR: ALCAR, or acetylcarnitine, is an essential nutrient, which means your body needs it but doesn’t naturally produce it. ALCAR will give your physiological processes an all-around boost. Cells rebuild faster (great for exercise,) immune functions are boosted (maintains health,) and mental and physical energy increase [8]. It does all this by getting fatty acids to your mitochondria (cellular power houses) faster.

Ashwaganda Root: Like the other two energy-boosting compounds, Ashwagandha root extract reduces cellular stress, allowing you to do more at least cost. It’ll also boost your immune functions, grant some neuroprotective benefits, and increase physical energy [9]. Crucially, it also indirectly promotes testosterone production: important for sexual health, overall energy, and muscle building [10].

REST

Valerian Root: While its mechanisms aren’t completely understood, valerian root functions by affecting your GABA system. This is the neurotransmitter responsible in large part for mood and calmness. At low doses, valerian has a calming effect, while at higher doses it’s been hailed as a sedative [11]. Either way, it’s a great way to transition into restful part of your day and prepare for sleep. You’ll want to take this and the rest of this part of the stack no more than an hour before bed.

Magnesium: Magnesium isn’t naturally produced in the body, but has a whole slew of benefits when you sufficiently supplement with it. It allows your muscles to relax (they tense up if you’re low on magnesium) and helps your body produce protein [12]. In other words, it’s a great way to follow up a strenuous day and make sure your body fully maximizes its recovery phase.

GABA: As you may have guessed from the name, GABA directly affects your GABA transmitters, meaning it will work synergistically with your valerian and theanine supplements. On its own, it’s a powerful amino acid that helps reduce stress and anxiety while increasing nerve signaling. Cap off your stack with this to make sure your sleeping body is doing everything it can to recover and prepare for the next day.

Remember, as with any stack, it’s important to cycle your nootropics to maintain maximum efficiency. Look to take a day or two off every few weeks, or to cycle your nootropics individually.

SOURCES:

  1.  http://emedicine.medscape.com/article/1182710-overview
  2.  http://www.drhoffman.com/page.cfm/417
  3. http://jn.nutrition.org/content/138/8/1572S.long
  4.  http://examine.com/supplements/Noopept/
  5.  http://examine.com/supplements/Yamabushitake/
  6. http://curezone.org/forums/am.asp?i=587180
  7. http://examine.com/supplements/Rhodiola+Rosea/
  8. http://examine.com/supplements/L-Carnitine/
  9. http://www.lef.org/magazine/mag2006/jun2006_report_ashwa_01.htm
  10.  http://nutrientjournal.com/ashwagandha-extrac-may-suppress-cortisol-increased-testosterone/
  11. http://ods.od.nih.gov/factsheets/Valerian-HealthProfessional/
  12. http://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional

The Poor Man’s Nootropic Stack

If you’re a college student or fresh graduate, you’re probably on a limited budget and don’t have a lot of money to spend on nootropics. However, your mental performance shouldn’t suffer just because you’re tight on cash.

In fact, with long nights studying and stressful exams, you could probably use a boost more than most people. Make no mistake, nootropics can get expensive, but like anything else, there’s a smart way to make your money work. You can build your own nootropic stacks that rival expensive blends for pennies on the dollar if you play your cards right.

Introducing: The Poor Man’s Nootropic Stack!

This stack is made up of essential nootropics that should serve as a baseline for anyone looking to save money on nootropics. In addition to being inexpensive, these are also very effective.

This stack includes nootropics that:

Limited funds? Don't sacrifice your brain power, try out the Poor Man's Nootropic stack!

Limited funds? Don’t sacrifice your brain power, try out the Poor Man’s Nootropic stack!

  1. Have a broad base of effects and lasting impact. These are considered the basics and a good foundation for any stack.
  2. Synergize with other nootropics included in the stack. These all work well together and, in some cases, will provide an added benefit over taking them individually.
  3. Are inexpensive. Since they’re the essentials, most are available in bulk powders or in other inexpensive forms that will allow you to stock up without breaking the bank.

Piracetam – Because it’s one of the oldest and most widely studied nootropics, piracetam is the superstar of the budget stack. Piracetam offers benefits for memory, learning, focus, concentration and mental performance in general. Bulk orders of piracetam can make it an extremely cost-effective supplement.

Caffeine – Caffeine has been used for ages by anyone trying to burn some midnight oil. What most people don’t know is that when used strategically, caffeine offers fantastic nootropic benefits. By consuming measured doses over time, caffeine can keep your mental energy levels steady and improve your focus. It’s also inexpensive. Bulk powder is available online, but if you want to go really cheap, you can consume coffee or other caffeinated beverages throughout the day in measured doses.

L-theanine – Providing anti-anxiety effects, l-theanine can be effective at helping you relax and focus. However, where it benefits you the most is when l-theanine is paired with caffeine. The two

Tea is a common source of theanine

Tea is a common source of theanine

have fantastic synergy that provides you with a calm, focused energy without caffeine jitters. This combination is already present at low levels in many teas; you’re just taking it up a notch to get the full effect.

CDP Choline – Choline is considered brain fuel. It keeps the furnace burning throughout the day and keeps you thinking sharp. Choline is another nootropic that offers synergistic benefits. Since piracetam increases choline uptake, adding a choline supplement can ensure that you’re getting the most out of your piracetam.

Noopept – Similar to piracetam, noopept is in the “racetam” family of nootropics. It offers the same benefits of improvements in memory, learning and mental performance. However, noopept powder is 1000x more potent than piracetam, so a much lower dose is required. Because of this, noopept makes a great addition to the Poor Man’s Nootropic stack with doses around $0.02 when purchased in bulk sizes.

Fish Oil – While not technically considered a nootropic, fish oil contains EPA and DHA which offer many neuroprotective benefits. In some cases fish oil has even been used to effectively deal with mood disorders.

That’s it! These are all you need to get smarter on a budget. Sure, it’s called the Poor Man’s Stack, but this could also be considered the “Smart Man’s Stack”. Why spend the money if you don’t have to? The nootropics listed here are enough to benefit anyone looking for a mental edge, no matter the budget!

Top Nootropics: Discover the Top 10 Nootropics

Top Nootropics Reviewed

Nootropics. Weird name, right? Believe it or not, you may have used a nootropic before without even knowing it!

If you work in a competitive business or are in college, chances are you’ve taken caffeine either in coffee, energy drinks, or supplement form. Caffeine is the world’s most widely-used and recognized nootropic.

Of course that does not mean it is the most effective. Many individuals are just simply unaware that there are better ways to focus while working or studying. What’s more, nootropics are able to unlock your cognitive potential!

So What Are Nootropics?

This unlocking does not mean you will suddenly find yourself in the premise of the movie Limitless, which brought nootropics to the attention of moviegoers everywhere. These aren’t magic powders to make you a genius. However, you may find you make connections more quickly, words flow more easily, and your motivation to get work done more readily available and longer lasting.

The word nootropic means “acting on the mind,” and that’s what these supplements are designed to do. They can enhance memory, cognitive function, and learning ability if taken correctly and at the right dosage.

There is a lot of information and misinformation available via the internet today concerning nootropics, especially when it comes to what is the best.

Top Nootropics

Below are the 10 top nootropics. This list is based on the effectiveness of the nootropic as a whole, the efficiency of the nootropic’s performance, and its accessibility to consumers:

  1. Noopept – Noopept is a quasi-member of the racetam family of nootropics and one of the most potent nootropics of its kind. It’s available in capsules as well as bulk powder. It improves cognition and enhances all the senses as well as imparts a great sense of physical, mental, and emotional well-being.
  2. Aniracetam – Another member of the racetam family, aniracetam helps creativity, memory, and intelligence; it also has anti-stress properties. For many beginners looking for a first nootropic to buy, aniracetam comes highly recommended.
  3. Pramiracetam – Pramiracetam can brighten up the brain and is great for those who suffer from poor concentration. Pramiracetam works in synergy with various other cognitive-enhancing products, such as choline, and as such has a very potent effect.
  4. Sulbutiamine – This is a synthesized version of Vitamin B1 (Thiamin) that helps elevate mood. It passes the blood-brain barrier with relative ease and helps elevate mood.
  5. L-theanine  – Interestingly, this is a non-essential amino acid which is most commonly found in tea. It is particularly good to take before an exam or presentation as it lowers stress levels. In combination with caffeine, l-theanine can give a calm, focused energy.
  6. NALT – N-Acetyl L-Tyrosine or NALT is an excellent mood elevator which enhances well-being and combats mental fatigue.
  7. CDP Choline  – This supplement is excellent for brain and neural function. Many users opt to stack choline with racetams as racetams often use up acetylcholine within the brain which can sometimes cause headaches.
  8. Alpha GPC – Another form of choline, this is found naturally both in milk and in the brain and has a positive effect on cognition.
  9. Beta Phenylethylamine (PEA) – PEA or phenylethlamine is primarily used for mood and has an effect which you are very likely to recognize. You know those feel good vibes you get from eating chocolate? Well this works in the same way, just way more concentrated and enhanced! It also stacks well with aniracetam to boost cognition.
  10. Phosphatidylserine – This is found naturally within cell membranes. As a nootropic, it’s a brain booster and memory enhancer.

So there you have it, the top nootropics supplements on the market. This article should be enough to equip you with the information to research and to ascertain which one(s) are best and most suitable for you, your lifestyle, and, of course, your budget.

Where to Buy Noopept Online at the Best Quality and Price

Noopept is certainly one of the most effective and powerful Nootropic supplements available on the market today.

In fact, it is an excellent supplement to use by those who are looking to improve their memory, concentration, learning ability, and a number of other cognitive functions.

Of course, finding the highest quality at the best price for all your supplements is certainly one of the most important things as well.

Noopept Effects:

Before you buy Noopept, it is important to understand some of the things this supplement will do for you. It has been proven to increase memory, expand learning capacity, possibly lengthen attention span, and improve concentration and focus. It is also considered to be significantly more powerful than piracetam, which is the first Nootropic (and the standard to which all seem to be compared).

This supplement works by boosting the rate of acetylcholine synthesis and levels within the brain. This increase, in turn, helps to form new neurons and basically increase the overall efficiency of the nervous system.

Where to Buy Noopept and other Nootropics

One of the things that most of the noopept reviews leave out is where to actually buy the supplement, in this case where to buy noopept. There are several possible sources to consider. For example:

So, which is better? Obviously, if you base your decision on price alone the choice is clearly Health Supplement Wholesalers. Of course, there are a number of ways to determine the quality of nutritional supplements as well. You see, contrary to popular belief, not all nutritional supplements are created equal.

The first thing you need to watch for is the grade. There are, in fact, four different possible grades including pharmaceutical, medical, cosmetic (nutritional), and feed (or agricultural) grade. The highest quality of these is pharmaceutical grade, meaning that the supplement has been tested for its purity, dissolution, and absorption by an outside party.

Medical grade is also very high quality and a number of supplements you are familiar with, such as prenatal vitamins, will typically fall into this category.

Cosmetic or nutritional grade supplements are typically sold in health food stores and may not always have the same exact concentrations as what is listed on the label, especially if they have not been tested (some are, but many are not… there is no way to automatically tell).

When determining which supplement to use, never use anything less than cosmetic or nutritional grade. Even then, it is better to stick with medical grade or pharmaceutical grade for assurance. All of the supplements listed above should be examined for their grade. If the grades are equivalent, which they likely are in this case, then it makes sense to pick the one which is the best value. On this list that would clearly be the Health Supplement Wholesaler product for a mere $21.97. That is just $2.19 per gram.

Noopept and Exercise

Nootropics have become increasingly popular. Noopept is one of the newest entries in the family of racetams although it has a little bit different structure.

Noopept Defined

This peptide-derived supplement is closely related to the racetam family and was originally promoted in Russia and neighbouring countries. Noopept has been said to be more (up to 1000 times) powerful than piracetam (the first and most popular among the racetam family) and is therefore taken at a much lower dosage.

 

How does it work?

Like the other supplements in the racetam family, noopept is said to have a similar mechanism of action. Similar to piracetam, it has been shown to increase the spindle-like activity and alpha wave function in the brain. Noopept reacts with glutamatergic AMPA receptors, binding to them and thereby allowing them to move between brain cells, producing noopept’s effects in cognition. After consumption, the supplement is absorbed through the GI tract and has a very high oral bioavailability that enables easy blood-brain penetration. This crossing of the blood-brain barrier is the reason for the low dosage and high potency of the supplement.

 

What are the Noopept Effects and Dosing?

Like the other nootropics, noopept has the following effects:
• Enhanced memory and cognition;
• Lowered anxiety, irritability, and apathy;
• Mood-boosting qualities.

The recommended dosage of noopept is 10-40mg daily. One can obtain both noopept powder and capsules depending on preference. It is also a common practice to stack noopept with other nootropics such as choline or other racetams. However, considering the strength and cost of noopept, it is usually taken alone.

 

Does Noopept Help with Exercise?

According to users, noopept may have a positive effect on exercise. The effect that nootropics have on the brain is enough reason to believe that they can in turn affect exercise. Remember that everything we do starts in the brain. By enhancing the general performance of the brain, one can accomplish far more in the gym.

Enhanced perception and reflexes have been reported by noopept users, both of which are benefits that translate to exercise. According to information available on user forums, a common stack used to increase energy and focus is noopept and caffeine which users claim allows one to get more things done. Although the major noopept effects are on cognition and memory enhancement, like other racetams it is also able to aid in physical performance. Still, the intensity of the effect will vary from person to person.

Noopept and Megadosing

iStock_000018892265XSmall-300x225

Noopept has noticeable nootropic effects due to its high potency. Many people use noopept to improve mood, focus, and motivation.

What is Noopept?

Scientifically known as N-phenylacetyl-L-prolylglycine ethyl ester, this nootropic supplement is patented in the United States and in Russia where it is commonly used. Noopept derives from the racetam family and works in a similar manner as the other racetams but is up to 1000 times more potent than the most common racetam, piracetam.

Noopept is a peptide (a compound consisting of two or more amino acids linked in a chain) that has been shown to be more powerful than Piracetam. Aside from being a brain booster, it is also reported to have anti-inflammatory benefits and antioxidant qualities.

How does it work?

The method of action used by noopept is similar to the group of cognitive enhancers called racetams. Although the exact way that racetams function is yet to be understood, these compounds are said to work by activating the glutamic receptors and inhibiting the hydrolization of acetylcholine in the brain. The breakdown of acetylcholine (the brain’s primary neurotransmitter) is what causes memory loss and other degenerative effects in terms of cognition. Noopept also seems to stimulate an anxiolytic response in animal and human models as well as dopamine receptor and serotonin-receptor sites.

What are the benefits?

Some of the noticeable noopept effects are:

  • Increased overall cognitive performance,
  • Increased learning ability,
  • Enhanced memory,
  • Improved reflexes and perception,
  • Improved mood.

Noopept and Megadosing

The recommended dosage for noopept is 10-40mg a day. Noopept is known to be one of the nootropics that produces noticeable effects after short usage. This rapid action makes it a highly-potent supplement that is recommended to be taken carefully.

A common practice when it comes to supplementing with nootropics is called megadosing. Megadosing is the consumption of an exceptionally large dose of a supplement. In the case of noopept, some users have experimented with megadoses and received good results. Megadosing with up to 100mg of Noopept twice a day improves mood, sensory enhancement, and general cognition.

Before you decide to megadose with noopept, it is important to assess your tolerance at lower dosages.

Noopept vs Pramiracetam

 

The nootropics noopept and piracetam are two popular cognitive enhancers available on the market today. Both supplements are safe for consumption and are available in many countries.

Pramiracetam is a nootropic derived from piracetam and is considered to be more potent[1]. Noopept is a peptide-derived nootropic that is closely related to the racetam family.

Let’s go into a little detail on both of these supplements.

What is noopept?

This cognitive enhancer is said to be stronger than piracetam and thus much more potent (10-30mg of noopept vs. 2-4g of piracetam). This nootropic is a very popular memory supplement and is categorized as a neuroprotectant[2].

How does noopept work?

Noopept ‘s mechanism of action is similar to the that of the racetam family. This mechanism entails stimulating the acetylcholine system as well as dopamine receptor sites. Acetylcholine is the neurotransmitter responsible for learning, so boosting the amount and duration of exposure is obviously a major plus. Furthermore, noopept also stimulates certain serotonin receptors which contributes to its mood boosting qualities[3].

Benefits of noopept

Noopept comes with many benefits:

• Increase in attention and memory
• Improvement in reflexes and perception
• Enhancement in logical thinking
• Boost in mood

The recommended dosage for noopept is 10-30mg taken daily. Noopept effects vary from person to person and some noticeable side effects include headache, insomnia, and fatigue. Since noopept is extremely potent, dosage should be strictly adhered to.

What is pramiracetam?

Pramiracetam is a nootropic that belongs to the racetam family and has been in use since the early 1980s. It shows potential in cognitive enhancement and is used to help alleviate symptoms of cognitive diseases [4].

Pramiracetam How does it Work?

Like its compatriots in the racetam family, pramiracetam works by increasing the uptake of choline in the brain thereby aiding in the efficient functioning of the acetylcholine system. This efficiency contributes greatly to memory formation and general cognition[5]. Such a mechanism of action has made pramiracetam one of the favorites among the cognitive enhancer supplements.

Pramiracetam Benefits

The most recognized benefits of pramiracetam include:
• Enhancement in mood
• Increase in long and short-term memory
• Increase in blood flow in the brain
Neuroprotective qualities

Pramiracetam Dosage

Pramiracetam is considered one of the strongest racetams; the recommended dosage is 250mg per day[6]. Due to the bitter taste that pramiracetam powder has, many users opt to purchase pramiracetam capsules instead (or flavors can be used to mask the taste as well).

Noopept vs Pramiracetam

Noopept and pramiracetam have also been used together in a nootropic stack and users claim that the emotionally dulling effect of pramiracetam counters the irritability effect of noopept. [7].

Both supplements are among the list of the strongest (produces the most noticeable effect) nootropics. For first-time users, increased mental clarity and enhanced cognition are noticeable[8].

As to the question of noopept vs pramiracetam and which among the two is the better nootropic, there isn’t always a definite answer. It would really depend for what you are aiming. One thing is for sure: these two supplements are among the strongest and should be handled with care.

I personally prefer noopept as it requires a much smaller dosage, so I don’t need to order very much at a time.

Sources

1. http://en.wikipedia.org/wiki/Pramiracetam
2. http://www.ncbi.nlm.nih.gov/pubmed/2011259
3. http://onlinelibrary.wiley.com/doi/10.1002/ddr.430030503/abstract
4. http://www.braintropic.com/racetam-comparison/
5. http://www.longecity.org/forum/topic/60676-pramiracetam-noopept-exam-log/
6. http://www.whatarenootropics.com/what-best-racetam-nootropic/

The Top 3 Mood Boosting Nootropics

Many people are looking for safe and natural methods to help boost or improve their mood. Whether this means combating mood disorders or to improve concentration and help with a loss of memory, there are a number of supplements which can help. It has been estimated that nearly 10% of all Americans have some form of depression. This probably does not even include those with mild memory problems or those suffering from temporary mood issues. Some of the top nootropic supplements, a few of which are also considered to be cognitive enhancers, may be just what the doctor ordered.

Aniracetam

This is a well-documented memory supplement that is a favorite mood booster for many. One of its specific effects seems to be increasing energy levels, which helps to improve motivation. Users are better able to actually get started on projects and accomplish needed tasks. There are also more subtle (although still quite noticeable) effects on feelings of well-being. It should also be noted that not everyone will have these exact same reactions, so feel free to try one of the others on the list.

Sulbutiamine

Many times, a poor mood is the result of chemical imbalances within the brain or simply an ineffective method of transmitting some of the brain hormones. A good example of this would be dopamine, which scientists believe responsible for mood and movement. Sulbutiamine actually seems to have the effect of increasing the amount of dopamine circulating within the brain. Many people who have shyness often also have low dopamine levels. Interestingly enough, there does not appear to be any kind of amphetamine-like stimulation as a side effect. You can buy sulbutiamine here.

Noopept

This is another nootropic that is actually a bit similar to Aniracetam. Researchers think that they both effect dopamine and serotonin receptor sites in a similar fashion. Noopept is actually a bit stronger than Aniracetam, so it is certainly possible that one might be more to your liking than another. This supplement does appear to increase feelings of well-being and enhancing motivation. There have also been reports of some anxiolytic effects, although this does not occur in all users.

Nootropics have been studied fairly extensively, especially in recent years. There is also a lot of anecdotal evidence and user reports to indicate that they do have a positive mood-boosting effect. If this is something that sounds interesting, be sure to try one or all of these different mood-booster supplements.

PRL 8-53 Dosage, Experience, Benefits and Memory

I was reading a book on nootropics titled Encyclopedia of Mind Enhancing Foods, Drugs and Nutritional Substances by David W. Group. While I feel a lot of the information was irrelevant towards my goals, I found one compound that sounded really interesting.

Merely known as PRL 8-53, this strange substance can apparently greatly increase one’s short term memory as well as memory formation given the right circumstances.

PRL 8-53 and Memory

Finding the right prl 8-53 dosage can help enhance memory.

If you’ve ever read a book on random facts, you might know that the reason a lot of phone numbers are only seven digits is because that is what most people are capable of memorizing after a couple seconds of studying.

I’ve tested my short term memory on www.cambridgebrainsciences.com, and sure enough, on the digit memory test, I can memorize seven digits fairly easily. However, while under the effects of PRL 8-53, test subjects could memorize around 21 digits. Talk about statistically significant!

This sounded way too good to be true to me, so I did a little reading on it. Unfortunately, all the research on it was from the 1970’s and is very limited. I have not been able to find a reason as to why research was discontinued, but several theories on the internet float around. Perhaps funding was discontinued from pharmaceutical companies. Everything I read about PRL 8-53 seemed positive with nothing negative. So why don’t people know about it?

A similar substance created by the same creator Dr. Nikolas R Hanis, called PRL 8-147, was studied in the early 1980’s at the University of Colorado at Boulder. Though not as widely-tested (PRL 8-147 never passed rodent testing), it is similar in function and structure.

It is possible to order this compound, as there are numerous companies in China that can synthesize it, but with little information, and most of that old, I’m not sure I’m too keen to test it. I may revisit the idea later, but for now, my noopept powder is sufficient (by the way, if you were wondering, this is where I buy noopept).

PRL 8-53 Additional Benefits

Quick Facts
Scientific [1, 2]:

  • Improves short term memory in all individuals
  • Statistically significant increase in working memory for individuals with poor short term memory
  • No side effects noted in human trial
Anecdotal:

  • Anxiolytic effects in some, anxiogenic effects in others
  • Mixes poorly with antihistamines, causing tension headaches
  • Improves memory recall; degree of success varies from person to person

Given how popular this post is, I’ve decided to take another look at PRL 8-53 and see what new information has surfaced in the past year.

In the one human study done on PRL 8-53, there were some pretty amazing results. Each participant was given a placebo and PRL 8-53 at different times. They were then instructed to memorize 12 one syllable words.

While on the placebo, they experienced minor improvements in their memory tests. While on PRL 8-53, however, their scores often times doubled, even in individuals with poor short term memory [1].

Individuals with poor short term memory also saw additional benefits that those with strong short term memory did not. Working memory (keeping details in the brain until it can cement into long term memory) improved by a reasonable margin.

The study participants were asked to repeat back the memorized words after a 24 hours period and a 96 hour period. Individuals with poor short term memory saw marked improvement in their working memory; individuals with strong short term memory did not see a statistically significant increase.

So what does this mean for you? According to this study, individuals with poor short term memory can expect to see the greatest benefits. Not only will they be able to remember more information for short periods of time, their long term memory formation will see improvements as well. Individuals with strong short term memory can also experience benefits from PRL 8-53, but these are isolated to further improving their short term memory, but not memory formation.

PRL 8-53: Anecdotal Experiences

While PRL 8-53 only has one scientific study dedicated to human research, there are plenty of biohackers on reddit who have taken it upon themselves to give PRL 8-53 a try. By many accounts, PRL 8-53 is the strongest nootropic when it comes to actually feeling the effects. There is also debate as to whether it is actually a nootropic or a stimulant.

Nootropics to Try

PRL 8-53 recently became available on the market, but it is often hard to find. In the meantime, consider trying out some other well known, better tested nootropics.

Piracetam: This is the original racetam with the weakest potency. Piracetam is a good nootropic to start with for beginners.

Noopept: 1000x more potent than piracetam, noopept is an excellent brain booster. Many experienced noopept/nootropic users prefer noopept for its higher potency.

CDP Choline: This is good to take with racetams as it can mitigate any potential racetam headache. It is also has cognitive enhancing properties of its own.

What the redditors do agree on, however, is it certainly does seem easier to learn and remember information. The degree to how successful the memory recall and formation varies from user to user, but most individuals have had positive experiences.

In the same thread, however, one user complained of feeling “on edge and uncomfortable” particularly in social situations, but also while on their own as well. It also seems to interact poorly with antihistamines, causing tension headaches similar to caffeine withdrawal.

Another thread advises against taking PRL 8-53 sublingually as it numbs the mouth. Interestingly, this thread includes multiple accounts of anxiolytic effects, quite in contention with the previous account.

One user described it as “a combination of 2g phenethylamine and a 10mg dose of noopept. I feel that tingly/itchy feeling on my skin that I associate similar to phenethylamine and the anxiolytic effects of noopept”.

As this is a largely unstudied substance, it will probably be some time before true benefits and side effects are determined.

PRL 8-53 Dosage Information

I have to stress that it is not recommended at this time take PRL 8-53 as very few studies have been conducted. However, in the study referenced above individuals were given 5mg. The patent information available for PRL 8-53 suggests a range of 0.01-4mg/kg of bodyweight. However, as that is a very large range, the ideal range is 0.05-1.2 mg/kg [2]. This translates to 3.4mg-81.6mg for a 150 pound person and 4.55mg-109mg for a 200 pound person. In the human trial, no side effects were recorded; however, reduced motor activity was noted in mice and rats when given large doses of PRL 8-53 [2].

A far as the redditors’ dosing habits go, most agree effects set in quickly but the sensation of feeling the effects fade within 90 minutes or so. As such, many of them choose to take a 5mg dosage two to three times per day. So far, they have not reported any side effects of taking additional doses, but again I must stress they do so at their own risk.

Sources

  1. http://www.ncbi.nlm.nih.gov/pubmed/418433
  2. http://www.google.com/patents/US3792048

Additional Reading About PRL 8 53

  1. examine.com/supplements/PRL-8-53/