A reader recently wrote in asking for my input on their theoretical stack. After looking it over I realized this was a fairly extensive question that deserved a detailed response.

Many nootropic stacks are geared toward boosting one particular thing, usually memory or intelligence. But what about a stack that doesn’t stimulate a certain area per-se so much as give you an all-around platform for mental and physical health?

Keeping your brain and body healthy while building a strong mind and body connection is a sure fire way to see cognitive improvements across the board. It’s not just about enhancing your brain: it’s about giving your body the nutritional tools to keep itself in tip-top shape. Supplementation can be tricky, though, since overstimulation of one part of your brain can have negative effects on others.

If you’re looking for a more holistic stack, it’s crucial you have the right mix of supplements taken at the right time in the right combinations. With that in mind, here’s a three-part daily stack designed to maximize your brain’s own innate potential.

Morning (before meal):

Caffeine	50 mg
L-theanine	100 mg
Noopept	20 mg
Lion’s Mane Extract	1000 mg

Morning (after meal):

Pramiracetam	250 mg
Choline Bitarte	500 mg

Before work-out (or other exercise):

Rhodiola Rosea	250 mg
ALCAR	500 mg
Ashwaganda Root	950 mg
Lion’s Mane	1000 mg

Evening, before bed

L-theanine	100 mg
Valerian Root	200 mg
Magnesium	400 mg
GABA	400mg

Now it’s time for a closer examination of the how and why of this stack. Essentially, it’s targeting three crucial aspects of holistic health: focus, energy, and rest. A substance-by-substance breakdown of how you’re benefitting from this stack:

FOCUS

Caffeine/Theanine: Caffeine’s stimulatory effects aren’t exactly a secret; caffeine is the most common nootropic, even though it’s not usually perceived as such.  Here’s the thing: it’s way more than a jittery energy booster that makes you crash a few hours later.

Caffeine increases levels of numerous neurotransmitters – norepinephrine, acetylcholine, dopamine, serotonin, epinephrine, and glutamate [1]. All of these are associated with focus and mental performance. Its critical downside is its notorious “crash”. This is where a theanine supplement comes in.

Theanine, found naturally in green tea, boosts and normalizes your GABA function [2]. Broken down, this has a calming affect which is directly synergistic with caffeine. Add a spoonful of a theanine in your morning coffee and you’re basically looking at all the benefits of caffeine minus the crash and jitteriness [3]. It’s hands-down the ideal way to kick off your daily nootropic regime. Take theanine on its own in the evening to settle into a calm, relaxed state.

Noopept: An offspring of the esteemed racetam family, noopept has shown to have dramatic impacts on memory and cognition with little to no side effects [4]. Even better, noopept powder also boosts neuroprotective effects. So you’re not only improving your focus with a daily dose of a noopept powder – you’re making your brain safer and stronger.

Lion’s Mane Extract: Extract from lion’s mane mushrooms has a unique function: it stimulates nerve growth factor, or NGF [5]. NGF belongs to a family of proteins that play a part in maintaining and regenerating neurons during our adult life. Bad news is as we age, our body produces less and less.

Lion’s mane, however, ensures high levels. Absence of NGF has been linked to age related memory loss [6], so if you’re looking for long-term upkeep of your cognitive health, lion’s mane is crucial. You’ll want to take it again later, since cumulative dosing is more effective.

Pramiracetam/Choline: Pramiracetam, usually found in the form of pramiracetam powder, is a bit different from other substances on this list in that it’s fat-soluble. In other words, pramiracetam powder won’t get metabolized correctly if it isn’t broken down by some fat or oil. This makes it an ideal substance to follow up with after a meal. Taking pramiracetam with a choline source boosts pramiracetam powder’s efficacy while simultaneously keeping your acetylcholine levels from dropping too low.

ENERGY/PRE-WORKOUT

Rhodiola Rosea: Rhodiola Rosea is derived from a flower that has been used for centuries to prevent fatigue. As an adaptogen, it both stabilizes your physiological processes and reduces stress on cells. It gives you energy, boosts focus, and allows your body to work harder and longer with less fatigue [7]. It’s an ideal supplement to any physical activity – which is itself crucial to a healthy mind-body connection.

ALCAR: ALCAR, or acetylcarnitine, is an essential nutrient, which means your body needs it but doesn’t naturally produce it. ALCAR will give your physiological processes an all-around boost. Cells rebuild faster (great for exercise,) immune functions are boosted (maintains health,) and mental and physical energy increase [8]. It does all this by getting fatty acids to your mitochondria (cellular power houses) faster.

Ashwaganda Root: Like the other two energy-boosting compounds, Ashwagandha root extract reduces cellular stress, allowing you to do more at least cost. It’ll also boost your immune functions, grant some neuroprotective benefits, and increase physical energy [9]. Crucially, it also indirectly promotes testosterone production: important for sexual health, overall energy, and muscle building [10].

REST

Valerian Root: While its mechanisms aren’t completely understood, valerian root functions by affecting your GABA system. This is the neurotransmitter responsible in large part for mood and calmness. At low doses, valerian has a calming effect, while at higher doses it’s been hailed as a sedative [11]. Either way, it’s a great way to transition into restful part of your day and prepare for sleep. You’ll want to take this and the rest of this part of the stack no more than an hour before bed.

Magnesium: Magnesium isn’t naturally produced in the body, but has a whole slew of benefits when you sufficiently supplement with it. It allows your muscles to relax (they tense up if you’re low on magnesium) and helps your body produce protein [12]. In other words, it’s a great way to follow up a strenuous day and make sure your body fully maximizes its recovery phase.

GABA: As you may have guessed from the name, GABA directly affects your GABA transmitters, meaning it will work synergistically with your valerian and theanine supplements. On its own, it’s a powerful amino acid that helps reduce stress and anxiety while increasing nerve signaling. Cap off your stack with this to make sure your sleeping body is doing everything it can to recover and prepare for the next day.

Remember, as with any stack, it’s important to cycle your nootropics to maintain maximum efficiency. Look to take a day or two off every few weeks, or to cycle your nootropics individually.

SOURCES:

1.  http://emedicine.medscape.com/article/1182710-overview
2.  http://www.drhoffman.com/page.cfm/417
3. http://jn.nutrition.org/content/138/8/1572S.long
4.  http://examine.com/supplements/Noopept/
5.  http://examine.com/supplements/Yamabushitake/
6. http://curezone.org/forums/am.asp?i=587180
7. http://examine.com/supplements/Rhodiola+Rosea/
8. http://examine.com/supplements/L-Carnitine/
9. http://www.lef.org/magazine/mag2006/jun2006_report_ashwa_01.htm
10.  http://nutrientjournal.com/ashwagandha-extrac-may-suppress-cortisol-increased-testosterone/
11. http://ods.od.nih.gov/factsheets/Valerian-HealthProfessional/
12. http://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional