Custom Acetylcholine Enhancing Stack

This is a post sent in to us by Eric Balaster of Pure Nootropics. I thank him for taking the time to write this. Opinions expressed are those of the author.

Most beginners to nootropics typically start with one of two combinations. The first is caffeine and L-theanine, which has a variety of studies that can prove the synergy between the two. The other includes piracetam and choline, which was one of the first nootropic stacks developed in the 1970s. Since then, thousands of people have found piracetam useful for preventing neurological decline and improving memory.

The supplementation of choline with piracetam strongly improves the effects in both animal and human trials. However, utilizing the right choline source can make the effects even more pronounced. The objective of the choline supplementation is to provide a precursor to acetylcholine, but this custom stack can prove more beneficial.

All Angles of Acetylcholine

My custom acetylcholine enhancing stack for use with racetams is particularly useful because it attacks all angles of the neurotransmitter. Rather than simply providing raw materials for acetylcholine synthesis, it is useful to consider enzyme blockers and synergistic compounds that can increase cognitive function.

CDP Choline

CDP choline is not the most efficient choline source by weight, but there are a number of advantages. Alternatives like soy lecithin and choline bitartrate are poorly absorbed and utilized for acetylcholine synthesis in the brain. CDP choline has the added benefit of creating cytidine, which is quickly converted into uridine [1]. Many studies point towards uridine for providing positive neuro protective capabilities as well, which makes it nearly as useful as choline.

Dosage: 200 – 525 mg / day


Although CDP choline provides some raw materials for choline and uridine production, acetyl-L-carnitine (ALCAR) is also a useful agent. It is a basic amino acid that provides a number of physiological benefits (especially for vegetarians), but is particularly useful for acetylcholine synthesis [2] to aid CDP choline.

Dosage: 500 – 750 mg / day

Spanish Sage

To compound the supplemented choline, Spanish sage is an excellent inhibitor of cholinesterase, which is the enzyme responsible for preventing full acetylcholine usage. Only small doses are required to have the desired effect [3], but young and healthy adults [4] respond well to this natural herb.

Dosage: 200 – 300 mg dried sage leaf / day

Diet and Tracking Your Stack

Depending on the types of foods that you eat, getting enough choline might not be a huge problem. There is a lot of choline in eggs, dairy products, and even some vegetables, so your supplementation will vary largely depending on your dietary intake. Furthermore, it is useful to track your cognitive abilities throughout the experimentation phase. You may find through subjective testing that your doses of these ingredients are too high (and thus causing a headache).

The only way to really know whether the piracetam and choline stack is working to improve your memory is through significant cognitive testing. Using enzyme inhibitors and the right types of choline for synergistic interaction can vastly improve the efficacy of nootropics.



About the Author

Eric Balaster is a self-described biohacker and nootropic lover. He has turned his interest of biology and physiology into a business called Pure Nootropics that offers independent third-party smart drugs for safe and convenient consumption.