Noopept vs Pramiracetam


The nootropics noopept and piracetam are two popular cognitive enhancers available on the market today. Both supplements are safe for consumption and are available in many countries.

Pramiracetam is a nootropic derived from piracetam and is considered to be more potent[1]. Noopept is a peptide-derived nootropic that is closely related to the racetam family.

Let’s go into a little detail on both of these supplements.

What is noopept?

This cognitive enhancer is said to be stronger than piracetam and thus much more potent (10-30mg of noopept vs. 2-4g of piracetam). This nootropic is a very popular memory supplement and is categorized as a neuroprotectant and psychostimulant[2].

How does noopept work?

Noopept ‘s mechanism of action is similar to the that of the racetam family. Despite noopept not technically being categorized as a recetam, its mechanism of action still entails stimulating the acetylcholine system as well as dopamine receptor sites. Acetylcholine is the neurotransmitter responsible for learning, so boosting the amount and duration of exposure is obviously a major plus. Furthermore, noopept also stimulates certain serotonin receptors which contributes to its mood boosting qualities[3].

Benefits of noopept

Noopept comes with many benefits:

• Increase in attention and memory
• Improvement in reflexes and perception
• Enhancement in logical thinking
• Boost in mood

The recommended dosage for noopept is 10-30mg taken daily. Noopept effects vary from person to person and some noticeable side effects include headache, insomnia, and fatigue. Since noopept is extremely potent, dosage should be strictly adhered to.

What is pramiracetam?

Pramiracetam is a nootropic that belongs to the racetam family and has been in use since the early 1980s. It shows potential in cognitive enhancement and is used to help alleviate symptoms of cognitive diseases [4].

Pramiracetam How does it Work?

Like its compatriots in the racetam family, pramiracetam works by increasing the uptake of choline in the brain thereby aiding in the efficient functioning of the acetylcholine system. This efficiency contributes greatly to memory formation and general cognition[5]. Such a mechanism of action has made pramiracetam one of the favorites among the cognitive enhancer supplements.

Pramiracetam Benefits

The most recognized benefits of pramiracetam include:
• Enhancement in mood
• Increase in long and short-term memory formation
• Increase in blood flow in the brain
Neuroprotective qualities
• Decreases the influence of amnesiac drugs

Pramiracetam Dosage

Pramiracetam is considered one of the strongest racetams; the recommended dosage is 250mg per day[6]. More experienced users of pramiracetam can take up to 400mg to 500mg twice daily. Due to the bitter taste that pramiracetam powder has, many users opt to purchase pramiracetam capsules instead (or flavors can be used to mask the taste as well). Be sure not to take pramiracetam sublingually as it may cause chemical burns.

Noopept vs Pramiracetam

Noopept and pramiracetam have also been used together in a nootropic stack and users claim that the emotionally dulling effect of pramiracetam counters the irritability effect of noopept. [7].

Both supplements are among the list of the strongest (produces the most noticeable effect) nootropics. For first-time users, increased mental clarity and enhanced cognition are noticeable[8].

If you haven’t taken these nootropics before, start with one at a time so you can experience their benefits in isolation. Then, if you decide to stack them you will have a higher chance of comprehending any synergistic effects of the stack.

As to the question of noopept vs pramiracetam and which among the two is the better nootropic, there isn’t always a definite answer. It would really depend for what you are aiming. One thing is for sure: these two supplements are among the strongest and should be handled with care. One deciding factor could be the methods of administration (see below).

I personally prefer noopept as it requires a much smaller dosage, so I don’t need to order very much at a time. Pramiracetam tends to make me too serious and limits my creativity.

Differences In Administration

Noopept’s cognitive enhancing effects are also more pronounces when taken sublingually, usually with a microscoop placed under the tongue. This usually isn’t done with pramiracetam since it can be caustic if kept in contact with areas under the tongue. Due to pramiracetam’s lack of dosage administration choices, you are forced to wait longer due to regular oral administration.



CDP Choline vs Alpha GPC and Choline Bitartrate

Synergy in Common Choline and Racetam Stacks

One of the difficulties most nootropic enthusiasts have upon building their latest stack is picking a choline source. There are good arguments for many choline forms, but I think that, ultimately, it comes down to a matter of priority and stack synergy. I’ve picked what I consider the big three (choline bitartrate, CDP choline, and Alpha GPC) and have shown what the benefits are for each.

Choline Bitartrate:

This should be an appealing choice for anyone who does not have the extra cash to pick up CDP-choline or Alpha GPC. That really appears to be its “synergistic” function. Going with bitartrate might allow you to afford another ingredient for your stack or even just afford your basic racetam/choline supplement combination if money is tight.

Choline bitartrate is the cheapest choline supplement, but it’s also the least bioavailable. Unlike, CDP Choline and alpha-GPC, the bitartrate form doesn’t easily cross the blood-brain barrier.

Bitartrate is a precursor to acetylcholine. This choline source is about 40% choline by weight. However, due to its limited bioavailability, the amount of acetylcholine this helps create is far less.

Despite its reduced potency, the bitartrate form of choline is still sufficient for liver benefits of choline. But due to its limitation in passing the blood-brain barrier, this form of choline has limited nootropic properties and lacked evidence in boosting memory in healthy adults (source).

CDP Choline:

CDP choline can be considered a nootropic on its own given the evidence that it increases dopamine and acetylcholine receptor density, improves memory, and provides mental energy. Also, CDP choline breaks down in the body into choline and uridine. [1] If you are taking DHA as part of your stack, this will help create phosphotidylcholine. [1] Since CDP choline readily crosses the blood-brain barrier, there is little concern for waste.

According to studies, this is the best choline format for combating memory-related issues due to aging. It’s also effective in boosting memory in young adults. Other non-nootropic uses include being used as an anti-addictive supplement against cocaine.

If you’re looking to boost memory or use in your uridine, or Mr Happy, stack then this is the optimal choline supplement. If you’re not familiar with this stack, see the original thread or the experiential post on

Alpha GPC:

Alpha GPC is another choline source with its own nootropic effects with or without a racetam through its ability to improve memory, focus, and concentration. [2] Alpha GPC is shown to also use DHA to help promote nerve growth. [2] Alpha GPC powder is usually the most expensive of the three forms shown.

Despite being the most expensive, this choline format is the most efficient source of choline and easily passes the blood-brain barrier due to its phospholipid properties.

In order for the body to use alpha-GPC it normally converts phosphatidylcholine stores in the brain. Phosphatidylcholine is used for the production of cell membranes. Dietary sources of alpha-GPC are scarce, which makes supplementing with this version almost necessary if you want to preserve your body’s phosphatidylcholine stores

Notes on stacks:

If your stack has Lion’s Mane or noopept (both increase nerve growth factor), Alpha GPC powder might not be the way to go. Through a simple racetam/CDP choline/DHA/noopept stack, it seems that the synergistic functions of the four compounds would benefit each other the most. Maybe add some creatine and sulbutiamine, and you’ve got yourself a perfect brain booster and wallet lightener.

  2. Kidd, Parris M. “Neurodegeneration From Mitochondrial Insufficiency: Nutrients, Stem Cells, Growth Factors, And Prospects For Brain Rebuilding Using Integrative Management.” Alternative Medicine Review10.4 (2005): 268-293. Academic Search Elite. Web. 8 Sept. 2012.